HMR lignan (7-Hydroxymatairesinol)
Synopsis of HMR lignan
HMR lignan refers to 7-Hydroxymatairesinol (HMR), a type of plant lignan extracted primarily from the Norway spruce (Picea abies). It is a secoisolariciresinol-type lignan, a class of phytoestrogens (plant-based compounds with mild estrogen-like activity) that are metabolized in the human body by gut bacteria into enterolignans, particularly enterolactone, which exhibits hormone-modulating, antioxidant, and anti-inflammatory effects.
HMR lignan is used primarily in hormonal and longevity support supplements, particularly for women in menopause or perimenopause, and for men interested in prostate health. It helps balance estrogen levels, may ease symptoms of menopausal transition (hot flashes, mood swings), and supports breast, uterine, and prostate health by modulating estrogen receptor activity in a protective rather than stimulatory manner.
In addition to hormonal support, HMR lignan exhibits antioxidant and cardioprotective effects. It may help lower LDL cholesterol, reduce inflammation, and support overall metabolic health, making it useful in addressing cardiovascular risk factors associated with aging and hormonal shifts.
HMR lignan is typically found in capsule or softgel form, either as a stand-alone supplement or blended into hormone-balancing and longevity-focused formulas.
Historical Use
While HMR lignan in its isolated form is a modern nutraceutical compound, the use of lignan-rich plants has long been part of traditional diets and herbal medicine. Flaxseed, sesame, and whole grains—historically consumed across cultures—are naturally high in lignans and have been associated with reproductive health, digestive balance, and cardiovascular wellness.
The discovery of HMR from the Norway spruce represents a scientific evolution of this traditional lignan use, with research beginning in the 1990s and early 2000s. Its high bioavailability and efficient conversion to enterolactone have made it a promising addition to evidence-based natural hormone support protocols.
Today, HMR lignan is regarded as a plant-based, non-hormonal compound that gently supports hormonal balance, healthy aging, and antioxidant defense, offering a targeted, modern extension of the traditional health benefits of dietary lignans.
HMR lignan is used for these health conditions
Breast Lumps (Scientific)
Cancer (natural therapy for) (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cardiovascular Disease (Scientific)
Cholesterol (high) (Scientific)
Free Radical Damage (Scientific)
Inflammation (Scientific)
Menopause (Scientific)
HMR lignan is used to support these body systems
Breasts (Scientific)
Estrogen (Scientific)
Female Reproductive System (Scientific)
Prostate (Scientific)
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