Poppy

Poppy (Papaver somniferum L.): A Comprehensive Reference

1. Identity and Botanical Classification

1.1 Scientific and Common Names

Papaver somniferum L., commonly known as the opium poppy, belongs to the family Papaveraceae. The Latin name translates as "sleep-bringing poppy." In Unani medicine it is referred to as Tukhm Khashkhaash (the seeds), while in Ayurveda the seeds are sometimes called Kasa bijam in Sanskrit. It is also encountered under the names opium poppy, breadseed poppy, and garden poppy.

1.2 Botanical Description

Papaver somniferum is an annual herb of height 50–150 cm, having tapering roots and a glaucous stem and leaves. The opium poppy is a small annual; the bright, showy flowers of the genus Papaver range in color from white to deep reds and purples. The seeds vary in color from light cream to blue-black and are numerous and minutely pitted. Sap from the seed pods may be white, orange, or red. Poppy seeds form in smooth, round fruits called pods, on the end of the flower stalk.

1.3 Natural Source and Geographic Origin

P. somniferum is originally native to the warmer parts of Western Asia, from where it was taken to Greece. From Asia Minor, Arab traders took it to the Far Eastern countries, including India and China. It is now extensively cultivated in most states of Europe not for opium, as in India, Turkey, and Iran, but for the capsules and for the oil obtained from the seeds.

1.4 Common Forms and Preparations

The various parts of the plant yield distinct commercial and medicinal preparations:

• Whole poppy seeds: The seeds of Papaver somniferum L. are commonly consumed in food worldwide. The seeds, consumed raw or cooked, contain opiate alkaloids, primarily morphine (0–450 μg/g seeds) and codeine (0–57.1 μg/g seeds), but also lower concentrations of thebaine (0.3–41 μg/g), noscapine (0.84–230 μg/g), and papaverine (0–67 μg/g).
• Cold-pressed poppy seed oil: An overall chemical characterization has been made of poppy seeds, cold-pressed oil, and press cake, a by-product of the oil industry; the proximate composition, fatty acids, and vitamin E profiles of the oil fraction have been analysed.
• Opium latex (raw opium): In the traditional system of medicine, opium was prepared from the air-dried milky latex or juice of unripe seed capsules as a remedy for a number of diseases and disorders. Beside sugars, raw opium (opium crudum) contains proteins, latex, gum, and pectins, approximately 20% of alkaloids, which in large part are bound to meconic acid and lactic acid. Approximately half of the alkaloid content in opium is morphine, the rest divided among 30 other alkaloids — narcotine (~5%), papaverine (~1%), codeine (~0.5%), and thebaine (~0.15%).
• Poppy seed cake: Poppy cake is a partially defatted by-product of the oil industry with lower fat content than the seeds, but higher content of other elements — ash (10%), protein (26%), and fibre (38%).
• Ethiodized poppy seed oil (medical contrast medium): A radiopaque iodine-lipid emulsion derived from poppy seed oil, used in hysterosalpingography (see Section 5.4).
• Poppy seed tea (illicit): A supernatant extracted from poppy seeds coated with the naturally occurring opiates morphine, codeine, and thebaine; contaminated seeds can be washed and the supernatant (tea) collected for consumption.

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2. Traditional and Historical Use

2.1 Ancient Mesopotamia and the Near East

The earliest accounts of the use of poppy preparations date to the ancient Sumerians in Mesopotamia, where the plant was used medicinally and was known as hul gil (the plant of joy). The Sumerians grew poppy as far back as 3,400 BCE and cultivated the plant for its medicinal and recreational use. Art from the region appears to feature poppy seed pods in the hands of some of the great Sumerian rulers. As the Sumerians used the plant, word spread quickly to neighboring cultures, and cross-continent trading of poppy began, first gaining influence in Assyria and ancient Egypt.

Poppies were widely used during antiquity as a source of food, therapeutics, and poisons. The alimentary value of poppy seeds was likely known in the Neolithic age, and there is some evidence that the neuropsychopharmacological effects of poppy juice were exploited during the Minoan civilization in the eastern Mediterranean basin. The Minoan civilization dates the attribution to poppies of symbolic meanings connected with rites of agricultural fertility, and this symbolism persisted throughout antiquity, with poppies attributed to goddesses of fertility such as Demeter, Aphrodite, and Ceres.

2.2 Ancient Greece and Rome

The medicinal uses of poppy were described by the ancient Greeks, and opium as an addictive agent was identified by Arabic physicians more than 900 years ago. The Greek god of sleep, Hypnos, and the god of dreams, Morpheus, were often depicted holding poppies or crowned with poppy flowers. The Romans used poppy infusions as mild sedatives, and early physicians from Hippocrates to Galen mentioned poppy-based remedies for pain, insomnia, and digestive issues.

2.3 Arab and Persian Medicine

Galen (138–201 AD) and Rhazes (865–925 AD) gave detailed descriptions of these drugs, their actions, therapeutics, and uses. Authoritative Arabic and Persian medical works such as Firdous ul-Hikmat and Mujarbat Quanan not only described the properties of these drugs but also included formulations containing them. Potions containing cannabis and linctus containing opium were popular in Arabia, Persia, and Muslim India.

2.4 Unani Medicine

In Unani medicine, Tukhm Khashkhaash refers to the seeds of Papaver somniferum of the family Papaveraceae. The description of poppy seeds is mentioned in various classical Unani books. The renowned Unani scholar Avicenna described poppy seeds in his famous work The Canon of Medicine, writing that the small white seeds are obtained from the capsule of the white poppy plant, and seeds obtained before the incision of the capsule for the extraction of opium are considered of the best quality. They have been used for centuries for treating ailments including diarrhea, dysentery, cough, premature ejaculation, chronic cough, insomnia, and skin disorders, as well as serving as a nutritive food. Their antibacterial, anti-carcinogenic, and hypoglycemic potential has also been examined on a scientific basis.

Opium and cannabis have been employed as therapeutic agents by the Ayurveda and Unani Tibbi systems of medicine for over ten centuries. The Unani Tibbi system of medicine in India has a large number of preparations containing these drugs. Sanskrit names of cannabis and opium generally refer to their description, properties, and actions; Ayurveda describes the properties and actions of opium exudate, poppy seeds, and poppy capsules.

2.5 European Culinary and Folk Use

The story of poppy seeds begins deep in the Neolithic era, around 5000 BCE. Archaeological findings across Europe suggest that early agricultural societies cultivated the opium poppy plant, not just for its seeds, but also for its sap and beauty. Charred poppy seeds have been uncovered in prehistoric settlements in Switzerland, Germany, and the Balkans, indicating their dietary use and possibly ritual significance. In medieval and early modern Europe, poppy seeds became important baking ingredients. A liquid alcoholic extract named Elixir Paregorico® is extensively used for diarrheal diseases in Brazil.

2.6 Key Historical Milestone: Isolation of Morphine

More than 200 years ago, between 1803 and 1805, the pharmacologically active pure compound morphine was isolated by the German pharmacist Friedrich Sertürner from seed pods of the poppy, and is believed to be the first isolation of an active ingredient from a plant source.

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3. Key Constituents and Active Compounds

3.1 Alkaloids

Papaver somniferum L. (family Papaveraceae) is a species well known for its diverse alkaloids — 100 different benzylisoquinoline alkaloids (BIAs). About 2,500 substances are members of this structurally diverse class of metabolites known as benzylisoquinoline alkaloids (BIAs), which include the opiate drugs morphine and codeine. The benzylisoquinoline alkaloid family has shown a wide range of pharmacological activity, including antibacterial, antitussive, antispasmodic, and anticancer properties.

The primary alkaloids, found concentrated in the latex of the unripe seed capsules, are:

• Morphine: Morphine has a high affinity for the μ-opioid receptor as an agonistic ligand. Morphine behaves as a potent full agonist at the μ-receptor and has 200-fold greater affinity to the μ-opioid receptor than codeine.
• Codeine: The pharmacology of codeine is strongly related to that of morphine, as it is a precursor of morphine itself. Up to 20% of codeine can be converted to morphine.
• Thebaine: Thebaine is the key substrate for the synthesis of semi-synthetic opioid alkaloids and natural opioids such as morphine and codeine. Thebaine is able to stimulate opioid receptors only at very high concentrations (micromolar range).
• Papaverine: Papaverine is a vasodilator. Papaverine acts as a smooth muscle relaxant.
• Noscapine: Noscapine is an antitussive and mitotic inhibitor. Noscapine, primarily used as antitussive, is also under investigation for anticancer properties.
• Sanguinarine: Sanguinarine has antimicrobial properties.

Papaver somniferum is valued for its alkaloid content. The plant is a source of many pharmaceutical benzylisoquinoline alkaloids, including morphine, codeine, noscapine, thebaine, papaverine, and sanguinarine. Other constituents found in the plant include steroids, triterpenoids, flavonoids, phenylpropanoids, free amino acids, and essential oil.

3.2 Fatty Acids and Lipid Composition

In poppy seeds, the major fatty acid is linoleic acid (LA, C18:2n6c, approximately 63% in seeds), followed by oleic acid (C18:1n9c, approximately 23%), and then palmitic acid (C16:0, approximately 11%). In low-morphine yielding varieties, linoleic acid made up 70.7–75.2% of the fatty acids.

3.3 Tocopherols (Vitamin E)

All samples of seeds and oil present α- and γ-tocopherols (>21 and >25 mg/kg, respectively), and the fatty acids profile of the oil fraction is mainly composed of unsaturated fatty acids, where linoleic acid predominates (>50%). High amounts of γ-tocopherol have been detected, especially in variety 'Viola' (287 ± 34 mg/kg).

3.4 Macronutrients and Minerals

The proximate analysis of poppy seeds shows the following approximate composition: fat (440 g/kg), protein (211 g/kg), moisture (50 g/kg), ash (63 g/kg), crude fibre (62 g/kg), and total carbohydrates (236 g/kg). Potassium and calcium are the predominant mineral elements in the poppy seeds. Among the water-soluble vitamins determined, pantothenic acid was found at the highest level, followed by niacin and thiamin.

Regarding protein composition, the major amino acid in poppy seeds was determined to be glutamic acid (36 mg/g).

3.5 Sugars

The sugars detected in the plant are fructose, glucose, xylose, maltose, and arabinose, and the concentration of reducing sugars (14.50%) is higher than that of non-reducing sugars (3.62%).

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4. Mechanisms of Action

4.1 Opioid Receptor System

Morphine and other opioid drugs act on an endogenous opioidergic system which is not only involved in setting pain (nociceptive) threshold and controlling nociceptive processing but also participates in modulation of gastrointestinal (GI) function, endocrine and autonomic function, and possibly cognition.

The pharmacological effects of opioid drugs derive from their ability to interact with the μ-, δ-, and κ-opioid receptors. The μ-opioid receptor plays a crucial role not only in opioid-induced analgesia but also in the unwanted actions of opioids. Of the five major opium alkaloids found in opium poppy, the two most pharmacologically active compounds are morphine and codeine. These opium alkaloids bind to and act as agonists at opioid receptors, thereby producing psychoactive and other pharmacological effects. These effects include analgesia, euphoria, respiratory depression, decreased gastrointestinal motility, and physical and psychological dependence.

Based on human data, the EFSA CONTAM Panel confirms that the critical effects of morphine are on the central nervous system (CNS), mediated by its high affinity to the μ-opioid receptor as an agonistic ligand. These adverse effects include nausea, vomiting, sedation, drowsiness, euphoria, miosis, respiratory depression, and obstipation. Therapeutic doses of morphine may reduce attentiveness and reactive skills, with potential impact on driving and operating machinery.

4.2 Papaverine: Smooth Muscle Relaxation

Among some benzylisoquinoline alkaloids, papaverine possesses important pharmacological effects as a vasodilator. Papaverine inhibits phosphodiesterase enzymes, leading to elevated intracellular cyclic adenosine monophosphate (cAMP), which causes relaxation of smooth muscle; this is distinct from the opioid receptor mechanism of morphine and codeine.

4.3 Noscapine: Antitussive and Putative Anticancer Mechanisms

Noscapine acts as an antitussive and mitotic inhibitor. Research indicates that noscapine's antitussive activity operates through a non-opioid mechanism, and its mitotic inhibitor properties have prompted investigation into anticancer applications, though most evidence in this regard remains preclinical.

4.4 Biosynthetic Pathway

The biosynthetic pathway of major alkaloids in Papaver somniferum begins with the central intermediate (S)-reticuline, leading to papaverine via two hypothetical pathways (NH pathway and NH3 pathway), noscapine, and a common pathway of morphine, codeine, and thebaine. L-tyrosine serves as a precursor of several specific metabolites like BIAs.

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5. Scientific Evidence by Area of Use

5.1 Pain Management (Analgesia)

Opium poppy has been used as an antitussive and potent analgesic to alleviate mild to extreme pain since ancient times. In modern clinical medicine, purified alkaloids — primarily morphine and its semi-synthetic derivatives — are among the most important analgesic drugs in use. Their efficacy is established by decades of clinical study in acute and chronic pain, cancer pain, and postoperative pain.

Papaver somniferum L. is a historically significant medicinal plant primarily known for its potent alkaloids such as morphine, codeine, and thebaine. With the global rise in opioid use and misuse, understanding the medical potential and risks of poppy-derived compounds has gained renewed significance, particularly in contexts such as cancer-related pain and acute cardiogenic pulmonary edema (ACPE).

The lowest known single oral therapeutic dose of morphine reported is 1.9 mg, corresponding to 27 μg/kg body weight for an adult weighing 70 kg.

Evidence strength: Very strong for purified morphine and codeine in clinical medicine. For dietary poppy seeds or crude preparations as analgesics, there are no clinical trials to support these uses.

5.2 Cough Suppression (Antitussive Use)

Among benzylisoquinoline alkaloids, codeine possesses antitussive properties. Codeine-based cough preparations derived from Papaver somniferum alkaloids have been extensively used in clinical practice. Noscapine has likewise been studied as a non-opioid antitussive.

Evidence strength: Strong for pharmaceutical codeine formulations in clinical trials. Evidence for crude poppy preparations in cough is traditional and not supported by specific randomized controlled trials.

5.3 Gastrointestinal Effects (Antidiarrheal)

Poppy extracts have traditionally been used to relax smooth muscle tone, making them potentially useful in the treatment of diarrhea and abdominal cramping. The extract has been used as a sedative analgesic and antitussive. Morphine and other opioid drugs participate in modulation of gastrointestinal function.

Evidence strength: Well-established pharmacological mechanism (decreased GI motility via μ-opioid receptor agonism). Loperamide, a peripherally acting opioid agonist based on the same mechanism, is a licensed antidiarrheal. Clinical evidence for crude poppy extracts specifically is not established by controlled trials.

5.4 Reproductive Health: Hysterosalpingography and Fertility Enhancement

Oil-based contrast medium in hysterosalpingography has been recommended as an approach to improve fertility. A randomized clinical trial aimed to assess the effects of intrauterine oil-based contrast infusion on frozen embryo transfer (FET) prognosis and pregnancy outcomes among patients with unknown recurrent implantation failure (RIF).

A landmark multicenter randomized controlled trial published in the New England Journal of Medicine (Dreyer et al., 2017) investigated oil-based (ethiodized poppy seed oil, Lipiodol) versus water-based contrast medium in hysterosalpingography in 1,119 infertile women. A 2017 study in the New England Journal of Medicine involving 1,119 women found that women whose fallopian tubes were flushed with poppy seed oil showed a 40% pregnancy rate within six months, compared to 29% in the water-based group.

A subsequent multicenter randomized controlled trial (NCT03370575) involving 1,026 infertile women across 15 medical centers conducted between 2017 and 2019 confirmed these findings in a Chinese population. Regarding fertility-enhancing evaluation, the oil group showed an increased cumulative on-going pregnancy rate, on-going pregnancy within 6 months (29.1% vs. 20.1%), clinical pregnancy (39.5% vs. 29.1%), and live birth ≥24 weeks of gestation (36.1% vs. 27.7%), as well as a shorter time to pregnancy than the water group (all P < 0.01).

A 2022 retrospective real-world study further evaluated outcomes. This real-world study enrolled 1,053 infertile patients who underwent ethiodized poppy seed oil-based HSG to explore its fertility enhancement value. A total of 1,053 infertile patients underwent HSG using ethiodized poppy seed oil as the contrast medium; the live birth rate and 3-, 6-, and 12-month pregnancy rates were retrieved and adverse events were recorded. The 3-, 6-, 12-month, and total pregnancy rate was 22, 36.8, 50, and 53.8%, respectively. The total live birth rate was 42.7%.

Evidence strength: Moderate to strong. Multiple RCTs and a large real-world cohort support the fertility-enhancing effect of ethiodized poppy seed oil used as HSG contrast medium. The mechanism is not fully elucidated but may involve mechanical flushing of tubes and possible immunomodulatory effects of the iodized oil. This application is distinct from oral consumption of poppy seeds.

5.5 Cardiovascular Effects (Papaverine)

Among benzylisoquinoline alkaloids, papaverine possesses important vasodilator pharmacological effects. Purified papaverine is used clinically as a smooth muscle relaxant and vasodilator in conditions such as arterial spasm; however, this clinical use pertains to isolated pharmaceutical-grade papaverine, not to dietary poppy products.

Evidence strength: Evidence for purified papaverine in clinical medicine is established. Evidence specifically for poppy-based preparations for cardiovascular indications is not supported by clinical trial data.

5.6 Nutritional Effects and Glycemia

A registered clinical trial (NCT01579656) administered ground poppy seeds baked into a bran muffin to evaluate the effect on postprandial blood glucose response, vascular, appetite, and sensory parameters, but the results have not yet been posted.

Evidence strength: Insufficient — no published clinical results are currently available from this trial.

5.7 Anticancer Research (Noscapine and Poppy Seed Components)

Noscapine, primarily used as an antitussive, is also under investigation for anticancer properties. Poppy seeds significantly inhibited benzo[α]pyrene-induced squamous cell carcinomas in the stomachs of Swiss mice in an animal study. Most current evidence for anticancer activity of poppy constituents remains preclinical (in vitro and animal studies).

Evidence strength: Preliminary — in vitro and animal data only; no controlled clinical trials in humans have established anticancer efficacy of poppy seeds or crude extracts.

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6. Body Systems and Health Areas Associated with Poppy

• Central Nervous System: Analgesic, sedative, and euphoric effects via μ-, δ-, and κ-opioid receptors; antitussive activity via central cough suppression.
• Gastrointestinal System: Morphine and other opioid drugs participate in modulation of gastrointestinal (GI) function. Decreased intestinal motility underlies both the antidiarrheal utility and the side effect of constipation (obstipation).
• Reproductive System: Ethiodized poppy seed oil used in hysterosalpingography has demonstrated fertility-enhancing effects in multiple clinical trials (see Section 5.4).
• Cardiovascular System: Papaverine acts as a smooth muscle relaxant and vasodilator. Therapeutic doses of morphine may reduce attentiveness and reactive skills, with potential impact on driving and operating machinery.
• Respiratory System: Adverse effects of morphine include respiratory depression. Codeine and noscapine are used therapeutically for cough suppression.
• Endocrine and Autonomic Systems: The opioidergic system participates in modulation of endocrine and autonomic function.

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7. Dosage Forms and Reported Dosages

Dosage information for poppy is highly context-dependent, differing markedly between food use, pharmaceutical preparations, and illicit use.

7.1 Pharmaceutical Alkaloids (Morphine)

The lowest known single oral therapeutic dose of morphine reported in the literature is 1.9 mg, corresponding to 27 μg/kg body weight for an adult weighing 70 kg.

7.2 Dietary Seed Consumption

In a controlled study, two 45 g raw poppy seed doses — each containing 15.7 mg morphine and 3.1 mg codeine — were administered 8 hours apart to 17 healthy adults. This illustrates that dietary exposure to opiate alkaloids from seeds can be pharmacologically meaningful.

Based on information from three European countries, it was estimated that daily intake of morphine from poppy seeds ranged from 3–90 μg/kg body weight per day. Portions of food items with high poppy seed content could provide morphine exposure in the range 38–200 μg/kg body weight per portion for adults.

7.3 Hysterosalpingography (Medical Procedure)

The oil-based contrast group received intrauterine infusion of ethiodized poppy seed oil at a dose of 5 ml before frozen embryo transfer.

7.4 General Guidance on Clinical Dosing

Clinical trials are lacking to guide dosage for poppy preparations used as dietary supplements or herbal remedies. No standardized supplement doses are established in recognized pharmacopeial monographs for oral poppy seed preparations.

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8. Safety Considerations and Interactions

8.1 EFSA Risk Assessment of Opium Alkaloids in Food

In October 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted the Scientific Opinion on the risks for public health related to the presence of opium alkaloids in poppy seeds. EFSA received analysis results for opium alkaloids — primarily morphine, codeine, thebaine, papaverine, and noscapine — in samples of poppy seeds, bakery products, and baking ingredients. Based on the relative prevalence of alkaloids present and their pharmacological potency, the CONTAM Panel concluded that the risk assessment could be based on dietary exposure to morphine alone.

The CONTAM Panel confirms the acute reference dose (ARfD) of 10 μg morphine/kg body weight (bw) and concluded that the concentration of codeine in poppy seed samples should be taken into account by converting codeine to morphine equivalents using a factor of 0.2. The ARfD is therefore a group ARfD for morphine and codeine, expressed in morphine equivalents.

From evaluation of extensive scientific literature, the EFSA panel concluded that it was possible for an individual to suffer effects from ingestion of poppy seed products.

8.2 Surface Contamination vs. Internal Alkaloid Content

Poppy seeds do not contain the opium alkaloids internally but can become contaminated with alkaloids as a result of insect damage or through poor harvesting practices. It has been shown that washing and other pre-treatments of the seeds can reduce morphine levels by up to 90%; it is believed that the alkaloid content of poppy seeds is due to external contamination from the pod previously containing the latex and not from the inside of the seeds.

8.3 False-Positive Drug Tests

Of the opium alkaloids found on poppy seeds, morphine and codeine are the most pharmacologically active and have been detected in biological matrices collected in workplace and roadside drug testing, resulting in positive opiate results. Normal poppy seed consumption is generally regarded as safe. During food processing, the morphine content is considerably reduced (up to 90%). The possibility of false-positive opiate drug tests after poppy food ingestion exists, and there are no unambiguous markers available to differentiate poppy food ingestion from heroin or pharmaceutical morphine use.

One study found morphine levels high enough to result in positive enzyme immunoassay (EIA) testing after ingestion of 1 poppy seed muffin or 2 poppy seed bagels. Although consuming poppy seeds may result in positive morphine or codeine levels in biological matrices, semi-synthetic opioids such as oxycodone, hydromorphone, hydrocodone, and heroin are not found in poppy seeds, and the presence of any one of these compounds in a specimen is not consistent with ingestion of poppy seed food.

8.4 Poppy Seed Tea: Toxicity, Dependence, and Fatalities

Poppy seed tea can be consumed for the purposes of intoxication or for the treatment of pain, anxiety, or withdrawal from opioids or opiates. However, its use is not benign and presents a risk for misuse that can lead to dependence, accidental overdose, and death.

Users of poppy seed tea (PST) can consume several hundred morphine milligram equivalents per day, and opioid dependence from PST use can develop.

Review of national databases identified 18 cases of non-fatal overdose likely attributable to poppy, most involving poppy seed tea, as well as five additional deaths likely attributable to opioids in poppy found in FDA adverse event reporting systems. Including previously reported cases, there are now at least 19 U.S. deaths associated with poppy seeds in the literature.

Use during pregnancy can lead to neonatal abstinence syndrome in the newborn.

Poppy seeds can be purchased in an unwashed or unprocessed form, and these seeds can be contaminated with the opium alkaloids morphine, codeine, and thebaine on their surfaces. Poppy seeds that are commercially available for baking and other food products are legal to purchase, as they do not contain the opium alkaloids on their seed coats. Purchase and possession of unwashed or unprocessed seeds are not legal in the United States.

8.5 CNS and Respiratory Risks from Morphine

Adverse effects of morphine include nausea, vomiting, sedation, drowsiness, euphoria, miosis, respiratory depression, and obstipation. Opioids carry significant risks, including the potential for addiction, tolerance (requiring higher doses over time to achieve the same effect), dependence (leading to withdrawal symptoms upon cessation), respiratory depression, and overdose.

Pharmacological and toxic effects, abuse, and dependence liabilities of these alkaloids are qualitatively similar to those of other Schedule II opioid analgesics such as oxycodone and hydrocodone.

8.6 Effects in Pregnancy and Fetal Development

From data on humans and experimental animals, it is clear that morphine can interfere with brain development of the fetus resulting in behavioural effects at later life stages; however, data are too limited to derive a dose–response relationship.

8.7 Food Safety Status of the Seed

The seed is generally recognized as safe when used as food. This designation refers to culinary-grade, washed, processed poppy seeds used in normal food quantities, not to high-dose preparations or unwashed seeds.

8.8 Regulatory Context

The plant's components, particularly the opium extracted from it, are controlled substances due to their potent and potentially addictive nature, and their use is regulated in most parts of the world. Despite numerous pharmaceutical applications, these compounds are under strict regulation due to their potential for abuse and addiction.

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References

• Butnariu M et al. "Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications." Oxidative Medicine and Cellular Longevity, 2022. PMC9943628
• Rai PK et al. "Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence." PMC10154933
• Nunes F et al. "Nutritional and Chemical Characterization of Poppy Seeds, Cold-Pressed Oil, and Cake." PMC9562219
• EFSA CONTAM Panel. "Update of the Scientific Opinion on opium alkaloids in poppy seeds." EFSA Journal, 2018;16:e05243
• EFSA CONTAM Panel. "Update of the Scientific Opinion on opium alkaloids in poppy seeds." PMC7009406 (full text)
• Huestis MA et al. "Morphine and Codeine in Oral Fluid after Controlled Poppy Seed Administration." PMC4409445
• Lachenmeier DW et al. "Poppy seed foods and opiate drug testing — where are we today?" PubMed 19901868
• Multari S et al. "Opium Alkaloids in Harvested and Thermally Processed Poppy Seeds." Frontiers in Chemistry, 2020. PMC7482649
• Zhao J et al. "Ethiodized poppyseed oil-based contrast medium is superior to water-based contrast medium during hysterosalpingography." PMC8987810
• Li H et al. "Fertility Outcome and Safety of Ethiodized Poppy Seed Oil for Hysterosalpingography in 1,053 Infertile Patients." PMC9051392
• Hagan S et al. "Opioid Use Disorder from Poppy Seed Tea Use: A Case Report." PMC9887487
• Glatstein M et al. "Opioid exposure associated with poppy consumption reported to poison control centers and the U.S. Food and Drug Administration." Clinical Toxicology, 2021
• Hagan S et al. "Opioid use disorder from poppy seed tea successfully treated with buprenorphine in primary care." Addiction Science & Clinical Practice, 2021
• Moeller KE et al. "Toxicologic Testing for Opiates: Understanding False-Positive and False-Negative Test Results." PMC3505132
• Pathan H, Williams J. "Opioid receptors." BJA Education, 2012. Oxford Academic
• US Drug Enforcement Administration. "Unwashed Poppy Seed." DEA Diversion Control Division
• Nencini P. "The rules of drug taking: wine and poppy derivatives in the ancient world. VI. Poppies as a source of food and drug." PubMed 9178441
• Ansari N et al. "Traditional Uses, Phytochemistry and Pharmacological Activities of Papaver somniferum with Special Reference of Unani Medicine." Journal of Drug Delivery and Therapeutics, 2018
• Khatoon R et al. "Tukhm Khashkhaash (Poppy Seeds): A Unani Drug of Multitudinous Potential." Journal of Drug Delivery and Therapeutics, 2019
• Zimmermann M et al. "Fatty Acid Composition, Tocopherols, Volatile Compounds, and Sensory Evaluation of Low Morphine Yielding Varieties of Poppy Seeds and Oils." Journal of Agricultural and Food Chemistry, 2021
• Zulfiqar U et al. "Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application." PMC10095881
• Guo L et al. "Genome and transcriptome of Papaver somniferum Chinese landrace CHM." PMC7775465
• Dwarakanath C. "Use of opium and cannabis in the traditional systems of medicine in India." United Nations Office on Drugs and Crime Bulletin, 1965
• Toll L et al. "Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids." PMC6553708
• Herb Society of America. "Poppy seed: Papaver somniferum." Herb Society Monograph
• Drugs.com Natural Products. "Poppy: Uses, Benefits & Dosage."