Skip to main content
Envío gratis en todos los pedidos
888-559-3802
Volver
VitabaseIngredientes

β-nicotinamida mononucleótido (NMN)

Condiciones de Salud24
Tabla de contenidos

Otros Nombres

((2R,3S,4R,5R)-5-(3-carbamoylpyridinium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate(5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate1-Deoxy-1-(3-carbamoylpyridinio)-5-O-oxylatophosphonyl-β-D-ribofuranose1-[3,4-dihydroxy-5-[(hydroxy-oxido-phosphoryl)oxymethyl]oxolan-2-yl]pyridine-5-carboxamide3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'-phosphate, inner saltbeta-Nicotinamide mononucleotideNicotinamide D-ribonucleotideNicotinamide mononucleotideNicotinamide ribonucleoside 5'-phosphateNicotinamide ribonucleotideNicotinamide ribotideNICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATENicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphateNMNβ-D-NMNβ-Nicotinamide mononucleotideβ-Nicotinamide ribose monophosphateβ-NMN

Sinopsis

Historia

La carne de res ha desempeñado un papel significativo en la historia de la nutrición y la medicina tradicional en diversas culturas. Históricamente, la carne de res era más que un alimento básico; a menudo se consideraba un ingrediente restaurador, valorado por sus propiedades fortalecedoras. Las civilizaciones antiguas, como las de China y Europa, reconocían la carne de res como una fuente potente de nutrición, recomendando frecuentemente el caldo o los extractos de carne de res para ayudar a la recuperación de enfermedades, aumentar la vitalidad y mejorar la salud en general. En los siglos XIX y principios del XX, los extractos y esencias de carne de res se convirtieron en remedios medicinales populares, celebrados por su capacidad para fortalecer a los débiles, convalecientes y ancianos.

Los remedios tradicionales a menudo usaban la carne de res en forma de caldos o decociones, a veces combinados con otras hierbas medicinales para potenciar sus efectos terapéuticos. Por ejemplo, el caldo de huesos de res se hervía comúnmente a fuego lento con raíces, hongos o hierbas tónicas como el ginseng o el astrágalo en la medicina china, con la creencia de que apoyaba la función inmunológica, reponía la energía y nutría la sangre. En las tradiciones herbales occidentales, los extractos de carne de res se mezclaban ocasionalmente con plantas botánicas como la ortiga o el perejil para crear tónicos para la anemia y la debilidad general.

Los productos nutricionales modernos continúan aprovechando los beneficios de la carne de res, especialmente como una rica fuente de proteínas de alta calidad, hierro y nutrientes esenciales. Cuando se combina con ingredientes herbales, las fórmulas a base de carne de res pueden proporcionar un impulso sinérgico, apoyando la resiliencia física y la recuperación. En general, el uso histórico de la carne de res en remedios medicinales subraya sus contribuciones positivas a la salud y el bienestar, tanto como ingrediente independiente como en combinación armoniosa con hierbas.

Validación tradicional y científica

La carne de res ha sido consumida por los seres humanos durante miles de años y sigue siendo un alimento básico en las dietas de muchas culturas. Históricamente, ha sido valorada por su rico perfil de nutrientes, proporcionando proteínas esenciales, hierro, zinc y vitaminas del grupo B, particularmente la vitamina B12. Se sabe que estos nutrientes apoyan el crecimiento muscular, la función cognitiva y la vitalidad en general. Las sociedades tradicionales a menudo apreciaban la carne de res y las vísceras por su papel en el mantenimiento de la salud y la energía, especialmente en poblaciones con acceso limitado a fuentes de alimentos diversas.

La investigación científica moderna respalda muchas de estas creencias tradicionales. Los estudios clínicos indican que la carne de res es una fuente de hierro hemo altamente biodisponible, que es absorbido de manera más eficiente por el cuerpo en comparación con el hierro no hemo de fuentes vegetales. Esto es particularmente importante para abordar la anemia por deficiencia de hierro, una preocupación nutricional generalizada. Además, la carne de res proporciona proteínas de alta calidad, que contienen todos los aminoácidos esenciales necesarios para la reparación y el mantenimiento muscular. La presencia de ácido linoleico conjugado (CLA) y creatina en la carne de res también ha sido estudiada por sus posibles beneficios para la salud en el metabolismo y el rendimiento atlético.

Si bien existen preocupaciones con respecto al consumo de carne roja y su asociación con ciertas condiciones de salud, el consumo moderado de carne de res magra como parte de una dieta equilibrada está generalmente respaldado por las guías dietéticas actuales. Es importante señalar que se necesita más investigación para comprender completamente los impactos en la salud a largo plazo y la ingesta óptima de carne de res. En general, cuando se consume de manera responsable, la carne de res puede ser un contribuyente valioso a los productos nutricionales, apoyando las necesidades dietéticas y ofreciendo nutrientes esenciales que pueden ser difíciles de obtener de otras fuentes.

Condiciones de Salud

Condiciones de salud que β-nicotinamida mononucleótido (NMN) puede ayudar a apoyar.

  • HipocondríaCientífico

    NMN boosts NAD+, which activates the SIRT1/NQO-1 antioxidant axis and supports PARP-mediated DNA repair, reducing reactive oxygen species (ROS) and oxidative damage. In vitro studies in human endothelial cells confirm NMN inhibits H2O2-induced cytotoxicity and ROS production. Preclinical and in vitro/ex vivo evidence is robust, with limited direct human biomarker data.

  • A 12-week RCT (n=36) found NMN supplementation (250 mg/day) tended to reduce brachial-ankle pulse wave velocity, a marker of arterial stiffness, though the between-group difference did not reach statistical significance. A 2026 meta-analysis of multiple RCTs found NMN produced a statistically significant modest reduction in diastolic blood pressure (−2.15 mmHg) and significant systolic reductions in adults aged 60+. Animal studies show NMN reduces vascular oxidative stress and restores SIRT1 activity in vessels.

  • A 6-week double-blind RCT in 48 amateur runners found NMN supplementation significantly improved aerobic capacity and skeletal muscle oxygen utilization. A multicenter RCT (Yi et al., GeroScience 2022) in middle-aged adults showed NMN at 600–900 mg/day increased 6-minute walking distance. A systematic review of 10 RCTs in 437 patients found non-significantly improved physical performance parameters.

  • A landmark 10-week RCT in prediabetic postmenopausal women found NMN (250 mg/day) improved muscle insulin sensitivity and muscle NAD+ turnover. However, a 2024 meta-analysis of 8 RCTs found no significant pooled effect of NMN on fasting glucose, fasting insulin, or HbA1c in predominantly non-diabetic adults. Evidence is mixed and population-specific.

  • NMN is a direct precursor to NAD+, a coenzyme critical for mitochondrial energy production in brain cells. NAD+ levels decline with age, impairing cerebral bioenergetics and contributing to cognitive fatigue and brain fog. Preclinical studies show NMN prevents diabetes-induced cognitive impairment and restores hippocampal NAD+. A human RCT found NMN supplementation improved muscle metabolism; evidence for direct brain fog relief in humans is preliminary.

  • HisteriaCientífico

    NMN is a direct precursor to NAD+, the central coenzyme in mitochondrial energy metabolism (glycolysis, TCA cycle, oxidative phosphorylation). Clinical trials show NMN supplementation raises intracellular NAD+ and ATP levels, supports physical performance, and mitigates age-related mitochondrial decline.

  • NMN is a direct precursor to NAD+, which is central to mitochondrial ATP production and energy metabolism. A 12-week double-blind RCT in older Japanese adults (PMC8877443) studied NMN's effects on sleep quality, fatigue, and physical performance. Multiple clinical trials show NMN increases NAD+ levels and improves energy-related outcomes.

  • ApendicitisCientífico

    NMN activates the NAD+/SIRT1 pathway, which suppresses NF-κB and NLRP3 inflammasome activity, reducing pro-inflammatory cytokine signaling. In vitro studies in human primary endothelial cells and preclinical sepsis models demonstrate NMN attenuates inflammatory responses. A 2025 human skeletal muscle biopsy study found NMN suppressed exercise-induced TNF-α and IL-10 mRNA.

  • IncontinenciaCientífico

    NMN (β-Nicotinamide Mononucleotide) is an NAD+ precursor whose supplementation is supported by mechanistic and preclinical evidence relevant to cognitive decline and healthy aging. NAD+ levels decline with age in the brain, contributing to neurodegeneration, axonal degeneration, and cognitive impairment. Preclinical models show NMN improves cerebrovascular function, reduces hippocampal synaptic disruption, and restores cognitive performance. Human clinical trials confirm NMN raises blood NAD+ levels and is well-tolerated, though direct cognitive benefit in humans remains to be definitively established.

  • NMN is a direct precursor to NAD+, a coenzyme central to cellular energy metabolism. Clinical RCTs in older adults show NMN supplementation (150–1,200 mg/day) significantly increases blood NAD+ levels and improves physical performance markers. A systematic review of 10 RCTs found consistent improvements in physical performance parameters.

  • Animal studies show NMN restores ovarian NAD+ levels, prevents ovarian atrophy, improves oocyte quality and quantity, and reduces ovarian inflammation in aging mice. A retrospective clinical analysis in women with diminished ovarian reserve showed NMN pretreatment significantly improved follicle size, endometrial thickness, and pregnancy rates compared to controls.

  • BronquitisCientífico

    NMN is a direct NAD+ precursor; NAD+ levels decline with age and are critical for energy metabolism, DNA repair, and sirtuin activity. A randomized double-blind multicenter trial in 80 middle-aged adults confirmed NMN at 300–900 mg/day significantly raised blood NAD+ levels versus placebo. Human studies suggest potential benefits for metabolic health and physical function in older adults.

  • JuanetesCientífico

    Preclinical studies demonstrate NMN alleviates heart failure, myocardial ischemia/reperfusion injury, and atrial fibrillation through NAD+-dependent mechanisms. Human clinical data show NMN is safe with respect to cardiac biomarkers and ECG parameters. NMN improves myocardial hemodynamic parameters and reduces oxidative stress in aged animal hearts.

  • Olor de piesCientífico

    The first human evidence of NMN's metabolic effects (Yoshino et al., Science 2021) showed 250 mg/day NMN for 10 weeks significantly improved muscle insulin sensitivity, signaling (mTOR/Akt phosphorylation), and NAD+ turnover in prediabetic postmenopausal women. Pooled meta-analyses in non-diabetic populations show no significant effect, suggesting benefits may be specific to insulin-resistant individuals.

  • EscalofríosCientífico

    Preclinical studies show NMN prevents diabetes-induced hippocampal neuronal loss and memory deficits, and rescues neurovascular coupling and cerebromicrovascular endothelial function in aged mice. A small human RCT (n=20 older men, 250 mg/day, 12 weeks) increased blood NAD+ but did not show significant improvement on cognitive assessments, likely due to insufficient power.

  • GingivitisCientífico

    Clinical trials examining NMN's cardiometabolic effects have shown variable results, with some studies in metabolically compromised individuals (elevated BMI, hypertension, prediabetes) showing improvements in blood pressure, body weight, and insulin sensitivity. A 2024 review found NMN's effects on metabolic parameters are context-dependent and more pronounced in individuals with metabolic dysregulation.

  • NMN is a direct biosynthetic precursor to NAD+, a coenzyme central to cellular energy metabolism, glycolysis, the TCA cycle, and mitochondrial oxidative phosphorylation. Human clinical trials confirm that oral NMN reliably raises blood NAD+ levels. However, a 2024 meta-analysis of eight RCTs found no statistically significant improvements in standard metabolic markers—fasting glucose, insulin, HbA1c, HOMA-IR, or lipid profile—in predominantly non-diabetic adults. One notable RCT reported improved muscle insulin sensitivity in prediabetic women, suggesting benefits may be context- or population-dependent. Overall, the mechanistic rationale is well-established, but clinical evidence for meaningful metabolic benefit in humans remains limited and inconsistent.

  • NMN is a direct biosynthetic precursor to NAD⁺, a coenzyme indispensable for the TCA cycle, NADH-driven electron transport, and sirtuin-mediated mitochondrial quality control. NAD⁺ levels decline with age, impairing mitochondrial function; NMN supplementation in clinical trials raises NAD⁺ and has been associated with improved physical performance and mitochondrial markers.

  • NMN is a direct precursor to NAD+, a cofactor essential for mitochondrial energy production and sirtuin-mediated neuroprotection in peripheral nerve cells. NAD+ depletion is mechanistically implicated in axonal degeneration via the Wallerian pathway. NMN is listed in authoritative peripheral neuropathy evidence databases alongside methylcobalamin and ALC, and preclinical studies support its protective effects against neuropathy.

  • Multiple human RCTs support NMN's role in improving endurance. The Liao et al. 2021 RCT found significant improvements in VO2 peak and muscle oxygen utilization in runners. The Yi et al. 2022 multicenter RCT showed NMN at ≥600 mg/day significantly increased 6-minute walking distance in middle-aged adults.

  • ConjuntivitisCientífico

    NMN is a direct precursor to NAD+, whose depletion is increasingly recognized as a mechanism of post-illness fatigue—particularly in post-COVID-19 syndrome. Clinical studies in healthy adults show NMN supplementation increases blood NAD+ levels and improves physical performance and fatigue measures.

  • NMN is an NAD+ precursor with closely related mechanisms to nicotinamide riboside for post-viral mitochondrial recovery. Integrative post-viral recovery reviews (Liebertpub, 2025; Ayafusion citing research) include NMN as a NAD booster that supports energy production and reduces inflammation in long COVID. Clinical investigation is ongoing alongside NR.

  • A 12-week double-blind RCT in 108 older Japanese adults found NMN (250 mg/day) taken in the afternoon (NMN_PM group) showed the largest effect sizes for improved lower limb function and reduced drowsiness. However, no statistically significant between-group interaction was found for PSQI sleep quality scores overall.

  • DebilidadCientífico

    A human clinical study (n=10 healthy volunteers) using intravenous NMN (300 mg) found a significant reduction in blood triglyceride levels alongside increased NAD+ without adverse effects on blood cells or organ markers. Oral NMN trials have shown variable effects on lipid profiles in meta-analyses.

Sistemas Corporales

Sistemas corporales que β-nicotinamida mononucleótido (NMN) puede ayudar a apoyar.

  • No hay sistemas corporales disponibles.
Únete a nuestro boletín

Mantente informado. Mantente saludable.

Recibe consejos de suplementos de expertos, descuentos exclusivos y recomendaciones de productos en tu bandeja de entrada