Caraway

Caraway (Carum carvi L.): A Comprehensive Reference

1. Identity, Botanical Classification, and Natural Source

Caraway (Carum carvi L.) is a plant cultivated globally for its flavoring properties and as a source of essential oil, containing various chemical constituents like carvone and limonene, which contribute to its applications in food, cosmetics, and traditional medicine. Caraway is the dried fruit (often called a "seed") of the Carum carvi plant, a member of the parsley family (Apiaceae). Related to chervil, celery, carrot, lovage, dill, fennel, and parsley, the plant produces crescent-shaped brown fruits with five ridges and a strong, complex aroma.

The Carum genus has 25 species, of which Carum carvi or caraway is the only annual and biennial economical one, used as a spice, aperitif, and carminative in food and pharmaceutical industries. Caraway is a biennial herb. In the first year, it forms a rosette of feathery leaves; in the second, it sends up a tall flowering stalk with umbrella-shaped clusters of tiny white or pink flowers that turn into the fruit.

Caraway is native to parts of Europe, North Africa, and Western Asia. It is particularly popular in Central and Eastern European cuisines and has long been cultivated for its culinary and medicinal uses. In India, it is widely grown in the northern Himalayan region and is also propagated as a winter crop in Kashmir and surrounding areas.

Common Synonyms and Names

• Botanical/scientific name: Carum carvi L. (family Apiaceae/Umbelliferae)
• Indian name: Siya jeera (Hindi)
• Persian/traditional use name: Referenced in Persian traditional medicine texts
• Note on naming confusion: Caraway seed (Carum carvi) and cumin seed (Cuminum cyminum), both members of the Apiaceae family, share the same name in Finnish, leading to frequent confusion.

Plant Parts Used and Common Preparations

Essential oil, fixed oil, and many other valuable extractive compounds with industrial applications are prepared from caraway. Caraway oil is present in all parts of the plant, but its concentration is highest in its fruits and is extracted by hydro-distillation. Caraway chaff oil is produced by hydro-distillation of husks and stalks and contains less carvone and more terpenes. Common preparations include:

• Whole dried fruits ("seeds"): Used in food and as crude drug material
• Essential oil: Extracted by hydro-distillation; the primary medicinal preparation
• Aqueous infusion (tea): Made by steeping the fruits in hot water
• Liquid extracts and tinctures: Standardized preparations used in phytomedicine
• Pharmaceutical dosage forms recognized by EMA: Herbal preparation in liquid dosage forms for oral use, and herbal preparation in semi-solid dosage forms for cutaneous use.

2. Historical and Traditional Use

Ancient and Pre-Historical Evidence

Caraway's history goes back to prehistory — archaeobotanical remains in Swiss lake dwellings date to 5000 BCE. In classical Greek texts (Theophrastus, c. 4th century BCE), the seeds were valued as digestive spices. This is one of the oldest known cultivated spices in Europe; archaeologists have found caraway seeds in prehistoric dig sites dating back to the Stone Age.

Caraway was first mentioned as a digestive aid in the Egyptian Ebers Papyrus in about 1500 BCE. Historical records indicate its medicinal use dates back to ancient Egypt, and it has been employed in Europe since the Middle Ages.

Greco-Roman, Medieval, and Islamic Medicine

Early Greek and Roman physicians used caraway in cooking and for medicinal purposes. Caraway was even mentioned in Shakespeare's Henry IV to help aid digestion and relieve gas.

Persian traditional scholars used caraway to help with gas and stomach pain. Ibn Sina (Avicenna), the influential physician, also recommended caraway for stomach aches, burping, gas, and intestinal spasms.

Traditional Uses by Indication

Caraway is traditionally used for treatment of indigestion, pneumonia, and as an appetizer, galactagogue, and carminative. A broader range of traditional applications is documented across cultures:

• Digestive disorders: Caraway fruit infusion was a remedy for colic and digestive disorders, and to fight intestinal worms.
• Gastrointestinal symptoms: Caraway fruits were used for their stimulant, expectorant, and antispasmodic effects, and specifically for stomach aches, constipation, and nausea.
• Miscellaneous folk uses: Caraway fruits were used as a popular remedy to mask alcoholic breath, treat anemia, and as an antidote agent against venomous bites.
• Topical applications: Caraway oil and thyme oil — or caraway oil alone in ethanol and castor oil — were used for scabies and mycosis. For supporting digestive function and relief of colic and flatulence, a few drops of caraway oil were added to olive oil and topically rubbed over the pit of the stomach or abdomen.
• Lactation: Caraway is a purported galactogogue, but has also been used to decrease breastmilk oversupply in Persian traditional medicine. Maternal use was also advocated to reduce colic in the breastfed infant.
• Weight management: Caraway was the main ingredient of anti-obesity drugs in traditional medicine.

Ayurvedic and Indian Traditional Medicine

In the ancient Ayurvedic system, caraway seeds are used to balance both Vata and Kapha doshas, and due to its hot potency it is said to increase Pitta dosha in the body. It is described as a strong aromatic and stimulant herb used to calm spasms of the uterus and gastric tract, and is also used to relieve respiratory complaints as an expectorant.

3. Key Constituents and Active Compounds

Essential Oil Composition

Caraway fruits contain a valuable therapeutic greenish-yellow essential oil (3–7%), which is used in many therapeutic formulations from ancient times. The two main components of caraway oil are limonene and carvone, which together constitute approximately 95% of the essential oil.

Carvone (76.8–80.5%) and limonene (13.1–20.3%) are the dominant components among the approximately 41 identified volatile compounds. Other essential oil components from caraway fruits include dihydrocarveol, carveol, and d-carvone, which are responsible for the odor of caraway.

The monoterpene ketone carvone (p-mentha-6,8-dien-2-one) has a chiral carbon and is found in nature as two optical antipodes. The isomer R-(−)-carvone is the main component of the essential oil of Mentha spicata and is responsible for the minty odor and flavor. On the other hand, S-(+)-carvone is the only antipode found in the essential oil of caraway (Carum carvi L.).

Other Chemical Constituents

Caraway fruits contain essential oil (3–7%), fatty acids (10–18%) (primarily petroselinic, linoleic, and oleic acids), protein (approximately 20%), carbohydrate (approximately 15%), phenolic acids (caffeic acids), and flavonoids (quercetin, kaempferol). Tannins, alkaloids, and terpenoids are also present in the caraway aqueous extract.

Caraway also contains flavonoids such as quercetin-3-glucuronides, quercetin 3-O-caffeyl glucoside, isoquercitrin, and kaempferol 3-glucoside.

A comparative study on fatty acid contents among Tunisian, German, and Egyptian caraway ecotypes found that the Tunisian chemotype had the highest total fatty acid composition (7.3%), followed by German (5.7%) and Egyptian (2.9%). Petroselinic acid was the major fatty acid in all three ecotypes (around 30%), with linoleic acid contents of approximately 28–30%.

4. Established Mechanisms of Action

Antispasmodic / Spasmolytic Activity

Carvone and limonene, two major constituents of caraway oil, have been shown to inhibit contractions in guinea pig ileum preparations. Based on similar effects to the calcium channel blocker verapamil, it was suggested that the antispasmodic effects of carvone are mediated by a similar calcium channel-blocking action.

Pharmacological investigations showed that carvone exhibits multiple pharmacological properties including antibacterial, antifungal, antiparasitic, antioxidant, anti-inflammatory, and anticancer activities. The antimicrobial effects are related to the action of carvone on the cell membrane and ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve action on cellular and molecular targets such as induction of apoptosis, autophagy, and senescence.

One published study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of caraway's essential oil. The enantiomers tested showed pharmacological activity in guinea pig trachea and rat aorta smooth muscle. No differences were observed in the pharmacological profiles of the enantiomer pairs, though the oxygenated monoterpenes (+)-carvone and (−)-carvone were pharmacologically more effective than the hydrocarbon monoterpenes (+)-limonene and (−)-limonene.

Carminative Activity

Caraway (Carum carvi) is listed in Potter's New Cyclopaedia of Botanical Drugs and Preparations as a carminative. The carminative effect is generally attributed to the relaxation of smooth muscle in the gastrointestinal tract and the facilitation of gas expulsion, mediated largely by the spasmolytic properties of carvone and limonene described above.

Antifungal Mechanisms

Studies assessed the antifungal and anti-aflatoxin B1 mechanisms of carvone on Aspergillus flavus and showed that carvone disrupted the integrity of the cell wall and membrane, induced reactive oxygen species accumulation, caused DNA damage, triggered cell autophagy, and reduced ATP levels, which ultimately led to cell death. Carvone also inhibited spore formation of A. flavus by suppressing the transcription of spore development-related genes.

Anti-Quorum Sensing and Anti-Biofilm Activity

Caraway essential oil in sub-inhibitory concentration dramatically blocked protease activity, pyocyanin production, biofilm formation, and quorum sensing activity of Pseudomonas aeruginosa.

5. Scientific Evidence by Area of Use

5.1 Functional Dyspepsia and Gastrointestinal Disorders

This is the area with the strongest and most consistent human clinical evidence for caraway. Research has focused primarily on a proprietary fixed combination of peppermint oil and caraway oil, known by the trade name Menthacarin (containing 90 mg peppermint oil and 50 mg caraway oil per unit).

A systematic review and meta-analysis identified 5 randomized controlled trials (RCTs) with a total of 578 participants evaluating the combination of peppermint oil and caraway oil (POCO) in adults with functional dyspepsia (FD). The evidence suggests that a combination of peppermint oil and caraway oil is an effective and safe short-term treatment for FD.

A subsequent and more comprehensive systematic review and meta-analysis published in 2022 specifically evaluated the Menthacarin formulation: Five randomized trials involving 580 patients found significant effects of Menthacarin on symptoms of functional dyspepsia compared to placebo or similar effects compared to a reference drug. Seven other studies reported favorable results on therapeutic application in FD patients with concomitant Helicobacter pylori infection, in irritable bowel syndrome (IBS), and on tolerability in FD patients from 12 years of age.

Three trials in FD with 249 patients were eligible for meta-analysis. Results demonstrated a significant reduction in pain intensity (standardized mean difference: 0.80; 95% CI: 0.39–1.21) and a significant improvement on item 2 of the Clinical Global Impression Scale (risk ratio: 2.65; 95% CI: 1.81–3.87) for Menthacarin. Menthacarin was shown to be effective and safe for the treatment of FD and represents a promising option for symptoms of IBS.

Limitations: All eligible RCTs were based on a short treatment duration of 4 weeks, which means long-term efficacy and safety of the peppermint oil/caraway oil combination in FD remain unknown. Overall, the results of this meta-analysis should be interpreted with caution and confirmed in large-scale, long-term RCTs.

EMA regulatory position: The EMA's Committee on Herbal Medicinal Products (HMPC) recognizes caraway oil as a traditional herbal medicinal product for the symptomatic relief of digestive disorders such as bloating and flatulence. The HMPC conclusions on the use of caraway fruit medicines for the relief of digestive problems such as bloating and flatulence are based on "traditional use," meaning that, although there is insufficient evidence from clinical trials, the effectiveness of these herbal medicines is recognized based on long-standing use.

5.2 Irritable Bowel Syndrome (IBS)

Caraway oil applied topically to the abdomen has been reported to relieve IBS symptoms in patients. The most-studied approach involves the Menthacarin combination. Menthacarin, a proprietary fixed combination of Mentha x piperita L. and Carum carvi L. essential oils, is used clinically for the treatment of functional dyspepsia and irritable bowel syndrome. Rodent model data indicate that treatment effects of Menthacarin on visceral hypersensitivity could be mediated via the normalization of gut dysbiosis. However, the impact of Menthacarin on human bacterial gut microbiota has not yet been directly studied.

Evidence strength: Evidence for IBS is favorable but is derived mainly from secondary analyses and studies where IBS and FD were comorbid; dedicated IBS-only RCTs for the combination product are limited.

5.3 Body Weight Management and Obesity

Caraway was the main ingredient of anti-obesity drugs in traditional medicine, which has been confirmed in two modern clinical trials of human studies.

The most rigorous human study was a triple-blind, placebo-controlled RCT: Seventy overweight and obese, healthy, aerobic-trained adult females were randomly assigned to two groups (n = 35 per group). Participants received either 30 mL/day of caraway extract (CE) or placebo without changing their diet or physical activity. Subjects were examined at baseline and after 90 days for changes in body composition, anthropometric indices, and clinical and paraclinical variables. The treatment group, compared with placebo, showed a significant reduction of weight, body mass index, body fat percentage, and waist-to-hip ratio. No changes were observed in lipid profile, urine-specific gravity, and blood pressure of subjects.

Similar results were shown in another RCT by Hamidnia et al. (2018).

Evidence strength: Preliminary. Both trials were conducted in a specific population (physically active women) and did not independently confirm changes in metabolic markers such as lipids. Further replication in broader, diverse populations is required before firm conclusions can be drawn.

5.4 Antimicrobial Activity

The antimicrobial activity of caraway essential oil has been the subject of several in vitro studies. Caraway essential oil has demonstrated antioxidant, anticancer, hepatoprotective, nephroprotective, antiulcerogenic, spasmolytic, insecticidal, anticonvulsant, and antimicrobial activities — though most of these findings are preclinical.

In one study, the caraway essential oil — with carvone (58.2%) and limonene (38.5%) as the main compounds — was particularly active against all Vibrio spp., with bacteriostatic action against all tested strains and inhibition zones ranging from 8.66 mm to 37.33 mm depending on the species.

Caraway essential oil, comprising carvone and limonene as its major compounds, generated larger zones of inhibition against gram-positive Staphylococcus aureus than gram-negative Escherichia coli.

Evidence strength: In vitro and preclinical only. No human clinical trials have assessed caraway's antimicrobial activity as a primary endpoint. These findings do not translate directly to clinical applications in infectious disease.

5.5 Antioxidant Activity

Caraway essential oil (carvone/limonene chemotype) exhibits antioxidant activities as measured by four different assays (DPPH = 15 ± 0.23 mg/mL; reducing power = 7.8 ± 0.01 mg/mL; β-carotene = 3.9 ± 0.025 mg/mL; chelating power = 6.8 ± 0.05 mg/mL).

Evidence strength: In vitro only. The relevance of measured in vitro antioxidant capacity to in vivo health outcomes in humans is uncertain and cannot be extrapolated directly.

5.6 Blood Glucose Regulation

Diabetic rats treated daily with a single oral dose of carvone (50 mg/kg body weight) for 30 days showed a substantial decrease in plasma glucose and HbA1c levels, as well as a significant improvement in hemoglobin and insulin levels. Administration of carvone also restored the activity of carbohydrate metabolic enzymes, enzymic antioxidants, and hepatic marker enzymes in diabetic rats to near-normal levels. Nevertheless, more research and safety studies are required to further verify carvone's benefits.

Evidence strength: Animal data only (rodent models). No well-designed human clinical trials specifically examining caraway's effect on blood glucose in people with diabetes have been identified.

5.7 Galactogogue (Milk Production) Use

Caraway (Carum carvi) seeds contain numerous volatile oils, the most prominent being carvone and limonene. Caraway is a purported galactogogue but has also been used to decrease breastmilk oversupply in Persian traditional medicine. No scientifically valid clinical trials support these uses, although one small, old study found no galactogogue effect. Two studies found small but measurable amounts of d-carvone in the milk of mothers given the chemical experimentally.

Evidence strength: No clinical trial support. Use for lactation is based entirely on traditional practice, and the available experimental evidence does not confirm a galactogogue effect.

6. Body Systems and Health Areas

• Gastrointestinal system: The most evidence-supported area. Carminative, antispasmodic, and prokinetic effects relevant to functional dyspepsia, flatulence, bloating, colic, and IBS. According to the European Union herbal monograph, caraway is traditionally used for symptomatic relief of digestive disorders (bloating and flatulence).
• Body weight / metabolic: Preliminary clinical data on weight, BMI, and body fat in physically active women.
• Antimicrobial: In vitro and preclinical evidence against bacteria, fungi, and protozoa.
• Endocrine / metabolic: Animal data only on blood glucose regulation via carvone.
• Reproductive: Traditional use as uterine antispasmodic and galactogogue; no rigorous human evidence.
• Dermatological: Traditional topical use for scabies and eczema; preclinical anti-inflammatory data.
• Respiratory: Preclinical studies of carvone and limonene enantiomers show spasmolytic activity in guinea pig tracheal smooth muscle, suggesting theoretical potential for the treatment of respiratory system disorders. No human clinical data.

7. Dosage Forms and Reported Dosages

The following dosages are drawn directly from regulatory monographs and published clinical studies and are reported as they appear in those sources.

As Reported in Regulatory Monographs (EMA)

• The highest daily dose of caraway oil stipulated in the EMA monograph is 0.3 mL, which corresponds to approximately 273 mg of caraway oil (based on a density of 0.91 g/mL).
• According to the European Pharmacopoeia, caraway oil should contain 50–65% d-carvone.

As Used in Clinical Trials

• Menthacarin combination: The proprietary combination studied in functional dyspepsia trials consists of peppermint oil (90 mg WS® 1340) and caraway oil (50 mg WS® 1520).
• Anti-obesity study: In the Kazemipoor et al. 2013 RCT, 70 overweight and obese healthy aerobic-trained adult females were assigned to receive either 30 mL/day of caraway extract (CE) or placebo, without changing their diet or physical activity. Subjects were examined at baseline and after 90 days.

8. Safety Considerations and Drug Interactions

General Tolerability and GRAS Status

Caraway is "generally recognized as safe" (GRAS) by the U.S. Food and Drug Administration. It is usually well tolerated, with the primary side effects being gastrointestinal such as heartburn, eructation, flatulence, and nausea.

Side effects of the caraway–peppermint oil combination product include a burning sensation around the breastbone, belching, nausea, and vomiting.

Allergic Reactions and Cross-Reactivity

Caraway fruit medicines must not be used in patients who are hypersensitive (allergic) to caraway or other plants of the Apiaceae (Umbelliferae) family, including fennel, anise, celery, coriander, and dill.

Plants in the Apiaceae family contain profilin proteins which can cause allergic reactions in uncommon circumstances. Allergic reactions are most likely to be caused by Bet v 1-like proteins, which cause reactions in people sensitized to birch tree pollen and give oral allergy-type symptoms.

Caraway seeds contain essential oils including carvone, anethole, and limonene, which are compounds that can cause skin irritation in people who pick, plant, or process the plant.

Anecdotal evidence suggests that caraway may induce symptoms of food allergy in sensitized individuals; however, few studies have been reported, and it is possible that the allergy occurs more frequently than has been reported.

Drug Interactions

Caraway may increase the effects of diabetes medications (e.g., metformin, glyburide) and cause blood sugar levels to be too low. Caraway may also increase the effects of herbs that decrease blood sugar levels. This is based on preclinical data demonstrating hypoglycemic effects of carvone in animal models; robust human evidence for this interaction is lacking.

Caraway may also increase iron absorption.

A preclinical study in mice examined the pharmacokinetic interaction between caraway essential oil and paracetamol (acetaminophen): Caraway essential oil pretreatment induced a statistically significant increase in pharmacokinetic parameters (Cmax, AUC, AUC∞) of intraperitoneally applied paracetamol, indicating enhanced body exposure to the drug. However, after oral administration of paracetamol, the pharmacokinetic data showed a significant decrease compared to control values, indicating a decrease in drug presence in the organism. The clinical relevance of this animal study for humans is uncertain.

Use in Specific Populations

The use of caraway oil is not recommended in adults under 18 years of age due to insufficient data, but it can be used topically as an anti-colic and carminative agent in children or infants.

Toxicological studies on caraway fruit and caraway oil are limited. The genotoxic potential of caraway fruit or caraway oil has not been fully evaluated.

In the ESCOP monograph, it is cited that caraway oil applied to the backs of hairless mice produced no irritating effects. However, oil applied to intact or abraded rabbit skin was irritating.

References

• Mahboubi M. "Caraway as Important Medicinal Plants in Management of Diseases." Natural Products and Bioprospecting, 2019. PMC6328425.
• LactMed®. "Caraway." Drugs and Lactation Database. National Library of Medicine / NCBI Bookshelf.
• Cheng Y, et al. "A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis." PMC6885176. 2019.
• Madisch A, et al. "Menthacarin, a Proprietary Peppermint Oil and Caraway Oil Combination, Improves Multiple Complaints in Patients with Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis." Digestive Diseases, 2022. PMC10273916.
• Frontiers in Pharmacology. "Menthacarin alters cultured human fecal microbiota composition, resulting in increased SCFA production." 2025.
• European Medicines Agency (EMA). "European Union Herbal Monograph on Carum carvi L., aetheroleum." EMA/HMPC/715094/2013.
• European Medicines Agency (EMA). "Caraway Fruit, Carum carvi L., fructus — Summary for the Public." EMA HMPC.
• European Medicines Agency (EMA). "Assessment Report on Carum carvi L., fructus and Carum carvi L., aetheroleum." EMA HMPC.
• Kazemipoor M, et al. "Antiobesity Effect of Caraway Extract on Overweight and Obese Women: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial." Evidence-Based Complementary and Alternative Medicine, 2013. PubMed 24319489.
• Krueger D, et al. "Peppermint and caraway oils have muscle inhibitory and pro-secretory activity in the human intestine in vitro." Neurogastroenterology & Motility, 2020.
• Souza FV, et al. "(−)-Carvone: Antispasmodic effect and mode of action." Fitoterapia, 2013.
• de Sousa DP, et al. "Spasmolytic Activity of Carvone and Limonene Enantiomers." Natural Product Communications, 2015.
• Fitsiou E, et al. "Health Benefits and Pharmacological Properties of Carvone." PMC8698960. 2021.
• Elmahallawy EK, et al. "GC-MS Analysis and Microbiological Evaluation of Caraway Essential Oil as a Virulence Attenuating Agent against Pseudomonas aeruginosa." PMC9741284. 2022.
• Snoussi M, et al. "GC-MS Profiling, Vibriocidal, Antioxidant, Antibiofilm, and Anti-Quorum Sensing Properties of Carum carvi L. Essential Oil." PMC9032858. 2022.
• Samojlik I, et al. "Herb-drug interactions: the influence of essential oil of caraway (Carum carvi L.) on the pharmacokinetics of paracetamol." PMC3506285. 2012.
• PMC. "Carvone-Rich Essential Oils and Their Agrobiological Interactions: A Review." PMC12943060. 2025.
• May B, et al. "Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia." PubMed 11121917.