Argan nut oil

Argan Nut Oil (Argania spinosa Kernel Oil): A Comprehensive Reference

1. Identity: Botanical Name, Source, and Forms

1.1 Botanical and Chemical Identity

Argan oil is a vegetable oil extracted from the fruits of Argania spinosa L. tree, belonging to the Sapotaceae family, primarily found in Morocco. Botanically, the argan tree is the only species of the Sapotaceae family to live above the tropics. Its International Nomenclature of Cosmetic Ingredients (INCI) name is Argania spinosa kernel oil. There are two kinds of argan oils on the market, namely food argan oil and beauty (cosmetic) use, designated by the INCI name Argania spinosa kernel oil.

1.2 Natural Source and Geographic Distribution

The argan tree is slow-growing and thorny, well-adapted to the drylands of south-western Morocco. This plant is endemic to south-western Algeria and Morocco, with the species originally grown in southern Morocco and also found throughout south-western Algeria. Argan trees are thorny evergreens endemic to the argan forests of southwest Morocco, as well as parts of Algeria and Mauritania. The trees, which can grow as tall as 10 metres (33 feet) and live as long as 200 years, are drought resistant and serve as a buffer against the advance of the desert.

In its biotope, the argan tree plays an important ecological role, including a deep root system that protects the soil from water and wind erosion, while its shade maintains soil fertility by preserving moisture. Despite the ecological importance of argan trees and their economic value as a source of argan oil, the trees are threatened by use for firewood and building materials, by overharvesting the seeds, and by overgrazing.

1.3 Common Forms and Preparations

Depending on the method used to prepare argan kernels, two types of argan oil can be obtained: food or cosmetic grade. Cosmetic argan oil is prepared from unroasted kernels, whereas food argan oil is achieved by cold pressing kernels roasted for a few minutes. Currently, argan oil is mainly produced by women's cooperatives in Morocco using a semi-industrial mechanical extraction process. This allows the production of high-quality argan oil.

The traditional extraction process involves multiple stages. To extract the kernels, workers first dry argan fruit in the open air and then remove the fleshy pulp. Some producers remove the flesh mechanically without drying the fruit. Moroccans usually use the flesh as animal feed. Workers gently roast kernels they will use to make culinary argan oil. After the argan kernels cool, workers grind and press them.

In commerce, argan oil appears in the following forms:

• Virgin/cold-pressed food oil: Produced from lightly roasted kernels; used for culinary purposes.
• Cosmetic oil: Cold-pressed oil obtained from unroasted argan kernels, intended to be applied directly to the skin or hair, or to be an ingredient in other cosmetic preparations.
• Dietary supplement capsules: Encapsulated forms of the oil available as nutritional supplements.
• Cosmetic formulations: Given its advantages in skin application — including hydration, antiaging, and protection — argan oil can be used in both dermatological and cosmetic formulations. The preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique for dermal delivery.

2. Traditional and Historical Use

2.1 Historical Timeline

The therapeutic benefits of argan oil consumption have been claimed by natives of Morocco and explorers for more than eight centuries. The argan tree has long been central to the Berber culture of southern Morocco. It has been used for centuries by local communities for a variety of purposes, from medicine to food to the production of oil. The traditional method of extracting argan oil, which involves grinding the nuts by hand, has been passed down through generations and remains an essential part of the region's cultural heritage. The process of producing argan oil is a social activity, often carried out by women in cooperative settings, strengthening community bonds.

Since prehistoric times, through antiquity, and up to the present day, the argan tree has served both humans and animals. The famous explorer Leo Africanus mentions in his 16th-century accounts the use of argan oil for food and lighting.

2.2 Ethnobotanical Uses by the Amazigh (Berber) People

Argan oil has a long history of use. In traditional Amazigh society, the oil is used to treat skin conditions and joint pain and is cited for reducing the pain of arthritis and lowering cholesterol. Traditionally, argan oil has been well known for its cardioprotective properties and is also used in the treatment of skin infections.

Among eight disease categories treated with the argan tree, treatment of skin and subcutaneous diseases had a very highly significant value of the Fidelity of Local Use (FL) index (98%). Analysis of manuscripts collected in the study area revealed an ancient therapeutic use of the argan tree. The results also show that argan oil extracted from the seed is used to prepare authentic foods with significant nutritional value, especially Amlou.

Rheumatology uses argan oil, which is applied to the affected area as a skin lotion. Argan oil is traditionally advised as a hepatoprotective agent, as well as in cases of atherosclerosis or hypercholesterolemia, and is taken by mouth.

Traditionally, cosmetic argan oil has been claimed to cure all kinds of skin anomalies with particular effectiveness for juvenile acne and chickenpox. It is also claimed to reduce the formation of wrinkles. Argan oil is generally used in cosmetology as a moisturizer as well as to treat devitalized skin.

Argan oil is also used in cooking: a Moroccan dish called amlou is a paste made from argan oil, toasted and crushed almonds, and honey, usually served at breakfast or with tea.

2.3 UNESCO Recognition

The importance of the argan tree is widely recognised, with UNESCO even inscribing it on their Representative List of the Intangible Cultural Heritage of Humanity in 2014.

3. Key Constituents and Active Compounds

3.1 Fatty Acid Composition (Saponifiable Fraction)

Argan oil is principally composed of mono-unsaturated (up to 80%) and saturated (up to 20%) fatty acids. At the molecular level, glycerides constitute 99% of argan oil, of which 95% are triglycerides, comprised of oleic acid (43–49%), linoleic acid (29–36%), and trace amounts of linolenic acid. There are also small amounts of saturated fatty acids in triglycerides — stearic acid (4–7%) and palmitic acid (11–15%).

The fatty acid profiles in argan oils are very similar, with oleic acid (43%) and linoleic acid (36%) and their respective monoacylglycerols predominating. Argan oil has a fatty acid composition similar to sesame and peanut oils but contains a smaller amount of oleic acid (about 45%) than erucic-free olive and rapeseed oils (about 60%), which are considered the healthiest.

3.2 Unsaponifiable Fraction: Tocopherols

Argan oil is very rich in tocopherols. The total tocopherol content is between 60 and 90 mg/100 g. γ-tocopherol is the main tocopherol found in argan oil (between 81 and 92 g/100 g), followed by δ-tocopherol (6.2–12.8 g/100 g), α-tocopherol (2.4–6.5 g/100 g), and β-tocopherol (0.1–0.3 g/100 g).

The major vitamer identified in argan oil is γ-tocopherol with a mean of 483 ± 11 mg/kg, in contrast to α-tocopherol, which is the major vitamer in olive (190 ± 1 mg/kg) and sunflower oil (532 ± 6 mg/kg). γ-tocopherol is known for its role in the prevention of heart disease and prostate cancer.

3.3 Phytosterols

Argan oil lacks β-sitosterol (δ-5 sterol) but does contain spinasterol and schottenol (δ-7 sterols). Sterols present in argan oil constitute 20% of the unsaponifiable fraction. There are four sterols in argan oil: two major ones, spinasterol (44%) and dihydrospinasterol/schottenol (48%), and two minor ones, avenasterol and 8,22-stigmastadien-3β-ol. These sterols have a regenerating effect on the epidermis. Spinasterol has anticancer properties, while schottenol has both anticancer and cytotoxic properties.

3.4 Squalene

The squalene content in argan oil is approximately 3,130 mg/kg, while in olive oil it is 4,990 mg/kg and in sunflower oil it is only 60 mg/kg. The only hydrocarbon present in argan oil is squalene, and its content is approximately 0.3%. This compound helps remove xenobiotics.

3.5 Polyphenols and Other Minor Compounds

Derivatives of phenols present in argan oil include ferulic, caffeic, syringic, p-hydroxybenzoic, and vanillic acids; tyrosol; oleuropein; epicatechin; catechin; and catechol. Polyphenols are very valuable natural products with antioxidant properties. They protect cells against damage caused by free radicals. They can also prevent atherosclerosis, cancer progression, and the development of pathogens.

Argan oil also contains tocopherol content (with γ-tocopherol levels much higher than in other vegetable oils), polyphenolic substances, sterols, its distinctive fatty acid composition, melatonin, saponins, minerals, coenzyme Q10, and squalene, showing its potential for both pharmacological and nutritional purposes.

3.6 Triterpene Alcohols

Triterpene alcohols constitute 20% of the unsaponifiable fraction of argan oil. Triterpenoids such as lupenone, ursane, and oleanane enhance the anticancer and antidiabetic potential of argan oil.

3.7 Proposed Mechanisms of Action

Research studies have demonstrated that argan oil exhibits diverse pharmacological properties, including antioxidant, antimicrobial, anticancer, anti-inflammatory, antidiabetic, antihypercholesterolemic, antiatherogenic, and immunomodulatory effects. These effects are attributed to its main constituents, including oleic acid, linoleic acid, γ-tocopherol, α-tocopherol, and ferulic acid.

Different mechanisms of action involved in these effects include enhancement of antioxidant defense, reduction of oxidative stress, modulation of inflammation, stimulation of fatty acid oxidation, suppression of apoptosis, regulation of miRNA expression, elevation of acetylcholinesterase activity, activation of Krebs cycle enzymes, and restoration of mitochondrial function.

Together with the mono-unsaturated fatty acids, the minor components — polyphenols, tocopherols, sterols, squalene, and triterpene alcohols — are likely to be responsible for argan oil's beneficial effects.

The phenolic compound-rich fraction of argan oil effectively prevents the oxidation of human low-density lipoproteins (LDLs). Oleic acid supports the transport of active ingredients naturally present in argan oil into the skin.

4. Scientific Evidence by Area of Use

4.1 Cardiovascular and Lipid-Modifying Effects

This is the best-studied area of argan oil's health effects, with multiple human clinical trials and a meta-analysis available.

Meta-Analysis

A systematic review and meta-analysis investigated the effect of argan oil on plasma lipid concentrations through a systematic review of the literature; randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with argan oil on plasma/serum concentrations of at least one main lipid parameter were eligible for inclusion. Meta-analysis of data from five eligible trials with 292 participants showed a significant reduction in plasma concentrations of total cholesterol (WMD: −16.85 mg/dl, 95% CI [−25.10, −8.60], p < .001), LDL cholesterol (WMD: −11.67 mg/dl, 95% CI [−17.32, −6.01], p < .001), and triglycerides (WMD: −13.69 mg/dl, 95% CI [−25.80, −1.58], p = .027). Plasma HDL cholesterol concentrations were found to be increased (WMD: 4.14 mg/dl, 95% CI [0.86, 7.41], p = .013). Argan oil supplementation reduces total cholesterol, LDL cholesterol, and triglycerides and increases HDL cholesterol levels. However, larger clinical trials are needed to assess the impact of argan oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes.

Key Individual Clinical Trials

One controlled trial aimed to evaluate whether consumption of virgin argan oil (VAO) is associated with a change in serum lipids and reduces cardiovascular disease risk in healthy Moroccans. Sixty volunteers consumed butter (25 g/day) during a 2-week stabilization period and were randomly divided into two groups: the treatment group received 25 g/day of VAO during 3 weeks, and the control group received 25 g/day of extra-virgin olive oil. Subjects consuming argan oil showed lower plasma LDL cholesterol (12.7%, p < 0.05) and Lp(a) (25.3%, p < 0.05) compared to non-consumers. Plasma lipoperoxides were lower (58.3%, p < 0.01) and the molar ratio α-tocopherol/total cholesterol and α-tocopherol concentration were higher in consumers.

A further study sought to comprehensively determine the effects of argan oil supplementation on plasma lipid profile and antioxidant status of a group of healthy Algerian subjects. A total of twenty healthy subjects consumed 15 g/day of argan oil — with toasted bread — for breakfast during 4 weeks (intervention group), whereas twenty matched controls followed their habitual diet. At the end of the study, argan oil-supplemented subjects exhibited higher plasma vitamin E concentrations, lower total and LDL cholesterol, lower triglycerides, and an improved plasma and cellular antioxidant profile when compared with controls.

In one study of dyslipidemic patients, subjects were randomly assigned to an argan group — consuming 25 mL/day of argan oil at breakfast for 3 weeks — or a control group, in which argan oil was replaced by butter.

Diabetic Populations

In a study investigating the effect of argan oil consumption on serum lipids, apolipoproteins (AI and B), CRP, and LDL susceptibility to oxidation in type 2 diabetic patients, 86 type 2 diabetic patients with dyslipidemia were randomized to one group consuming 25 mL/day of argan oil during 3 weeks and a control group consuming 20 g/day of butter at breakfast. After argan oil intervention, serum triglycerides decreased by 11.84% (p = 0.001), total cholesterol by 9.13% (p = 0.01), and LDL cholesterol by 11.81% (p = 0.02). HDL cholesterol and ApoAI increased (10.51%, p = 0.01, and 9.40%, p = 0.045, respectively). Susceptibility of LDL to lipid peroxidation was significantly reduced. The authors concluded that argan oil may have an antiatherogenic effect by improving lipids and LDL oxidation susceptibility in type 2 diabetes patients with dyslipidemia.

Platelet Aggregation and Antithrombotic Activity

Argan oil has been shown to inhibit in vitro and ex vivo platelet aggregation without extending bleeding time. An in vivo antithrombotic activity of argan oil was examined in an experimental thrombosis model in mice (acute pulmonary thromboembolism). The authors suggest that argan oil might be an interesting natural dietary source for the nutritional prevention of hemostasis and cardiovascular disorders, though clinical trials would be necessary and relevant to confirm this hypothesis.

Evidence strength: Moderate. Multiple small RCTs and a meta-analysis of five trials (n=292) support lipid-lowering effects, but trial sizes are small and long-term cardiovascular outcome data are absent.

4.2 Dermatological Uses: Skin Hydration, Elasticity, and Aging

Argan oil is reputed to impart antiacne, antisebum, antiaging, moisturizing, and wound-healing activity, but clinical evidence is sparse.

Skin Hydration

A study evaluated the effect of daily consumption and/or application of argan oil on skin hydration in postmenopausal women. Sixty postmenopausal women consumed butter during the stabilization period and were randomly divided into two groups: the treatment group absorbed alimentary argan oil (n=30) and the control group consumed olive oil (n=30). Both groups applied cosmetic argan oil to the left volar forearm during a sixty-day period. Evaluation of transepidermal water loss (TEWL) and water content of the epidermis (WCE) was performed at day 0, day 30, and day 60. Consumption of argan oil led to a significant decrease in TEWL (p = 0.023) and a significant increase in WCE (p = 0.001).

In a small study, the nightly topical application of argan oil resulted in a moisturizing effect, and in statistically significant decreases in transepidermal water loss and increases in the water content of the epidermis.

Skin Elasticity (Postmenopausal Women)

A randomized controlled study was conducted to evaluate in postmenopausal women the effect of daily consumption and/or application of argan oil on skin elasticity. Sixty postmenopausal women consumed butter during the stabilization period and were randomly divided into two groups for the intervention period: the treatment group of 30 participants received dietary argan oil, the control group of 30 participants received olive oil, and both groups applied cosmetic argan oil to the left volar forearm during a 60-day period. It was suggested that the daily consumption and/or topical application of argan oil has an anti-aging effect on the skin, demonstrated by the improvement of skin elasticity, characterized by an increase of R-parameters (R2, R5, and R7) and a decrease of RRT.

Treatment with argan oil increased the level of vitamin E in postmenopausal women's blood more than treatment with olive oil, which can explain the improvement of skin elasticity with argan oil treatment. The synergistic antioxidant effect of vitamin E and ferulic acid plays a key role in the maintenance of skin elasticity through the decline in collagen and elastic fibers degradation in response to MMP inhibition activity.

Stretch Marks

A water-in-oil cream containing argan oil and emollient ingredients was developed. An in vivo study of clinical efficacy revealed a positive effect on increasing skin elasticity, suggesting that the cream may be helpful in the prevention or early treatment of stretch marks (striae distensae). The study revealed statistically significant changes in skin elasticity, but no significant changes in hydration and thickness of the epidermis, probably due to the short period of application of the cosmetic product. A small study of 22 people prone to stretch marks found that a cream containing argan oil improved skin elasticity compared to baseline measurements.

Evidence strength: Preliminary to moderate. Small RCTs show improvements in skin hydration and elasticity measures, particularly in postmenopausal women. Trial populations are small, studies are short-term, and several are conducted by the same research group. Independent replication is limited.

4.3 Antidiabetic and Metabolic Effects

Evidence for antidiabetic effects in humans is largely indirect (via lipid and antioxidant improvements in diabetic patients, as described in Section 4.1). Direct preclinical data come from animal studies.

A study evaluated the effect of roasted and unroasted argan seed oil on diabetic nephropathy. Both oils ameliorated significantly diabetic nephropathy symptoms. They limited the renal damage caused by streptozotocin and improved diabetes symptoms, including blood glucose levels, body weight, water intake, urinary volume, and kidney parameters. This activity could be attributed to the antioxidant effect of argan oil, enabling neutralization of free radicals and undertaking a fundamental role in preventing the onset of these complications. Based on these findings, argan oil could be used as a dietary supplement for people with diabetes as a preventive measure against the emergence of diabetic complications.

To date, no clinical study has investigated simultaneously the effects of argan oil on the three main cardiovascular risk factors associated with metabolic syndrome (hypertension, insulin resistance, and obesity) and on neuropathic pain. A preclinical study was designed to investigate whether a chronic treatment of twelve weeks with argan oil can prevent or ameliorate arterial hypertension, insulin resistance, obesity, allodynia, and alterations in plasma levels of triglycerides, free fatty acids, leptin, and adiponectin in glucose-fed rats.

Evidence strength: Weak for direct antidiabetic outcomes in humans. The positive findings in the diabetic lipid study (Section 4.1) are promising, but most antidiabetic data remain animal/in vitro. Clinical trials specifically targeting glycemic control are lacking.

4.4 Anticancer / Antiproliferative Activity

Research in this area is restricted to in vitro cell-line studies. There are no clinical trials demonstrating anticancer efficacy of argan oil in humans.

One study evaluated the antiproliferative effect of polyphenols and sterols extracted from virgin argan oil on three human prostatic cell lines (DU145, LNCaP, and PC3). Cytotoxicity, antiproliferative effects, and nuclear morphological changes were analyzed after treatment with sterols and polyphenols compared to 2-methoxyestradiol (2ME₂) as a positive control. Polyphenols and sterols of virgin argan oil exhibited a dose-response cytotoxic effect and antiproliferative action on all three tested cell lines. The antiproliferative effect of polyphenols on DU145 and LNCaP cell lines yielded GI₅₀ values of 73 and 70 µg/ml, respectively. The antiproliferative effect of sterols was 46 and 60 µg/ml as GI₅₀ for DU145 and LNCaP cell lines.

Tocopherols and saponins extracted from argan tree and 2-methoxyestradiol exhibit a dose-response cytotoxic effect and an antiproliferative action on the tested cell lines. The best antiproliferative effect of tocopherols was obtained with DU145 and LNCaP cell lines (GI₅₀ of 28 µg/ml and 32 µg/ml, respectively). The saponins fraction displayed the best antiproliferative effect on the PC3 cell line with 18 µg/ml as GI₅₀. These results confirm the antiproliferative effect of tocopherols and saponins from argan tree on hormone-dependent and hormone-independent prostate cancer cell lines, suggesting that argan oil is of potential interest in developing new strategies for prostate cancer prevention.

Dietary polyphenols may exert anticancer effects through several mechanisms, such as removal of carcinogenic agents, modulation of cancer cell signaling and antioxidant enzymatic activities, and induction of apoptosis as well as cell cycle arrest.

Evidence strength: Very preliminary — in vitro only. No human clinical trial data exist. Results from cell-line experiments cannot be extrapolated directly to clinical cancer prevention or treatment.

4.5 Antioxidant Activity

Argan oil is rich in unsaturated fatty acids and bioactive molecules, such as polyphenols, tocopherols, squalene, xanthophyll, CoQ10, and sterols. Multiple human studies have demonstrated improvements in antioxidant biomarkers following argan oil consumption. In argan oil consumers, plasma lipoperoxides were lower (58.3%, p < 0.01) and the molar ratio α-tocopherol/total cholesterol (21.6%, p < 0.05) and α-tocopherol concentration (13.4%, p < 0.05) were higher compared with non-consumers.

4.6 Protective Effects Against Organ Toxicity (Preclinical Data)

Based on results from various in vitro and in vivo investigations, the beneficial action of argan oil against xenobiotic-induced toxicities was analyzed. Argan oil and its main constituents have reduced neurotoxicity, hepatotoxicity, nephrotoxicity, pneumotoxicity, thyroid toxicity, hematotoxicity, immunotoxicity, genotoxicity, and colon toxicity induced by different natural and chemical xenobiotics. However, clinical trials are necessary to verify the protective effects of this oil in human intoxications caused by both natural and chemical xenobiotics.

4.7 Gut Microbiota

Argan oil, rich in unsaturated fatty acids and polyphenols, exerts beneficial effects on both the intestinal and skin microbiotas. In the gut, it promotes the growth of beneficial bacteria, such as lactobacilli, while reducing pathogenic bacteria, due to its anti-inflammatory properties that help maintain microbial balance. This evidence is largely preclinical and exploratory.

5. Body Systems and Health Areas Associated with Argan Oil

Based on the available literature, argan oil has been studied or is traditionally associated with the following body systems:

• Cardiovascular system: Lipid-lowering, antioxidant, antiatherogenic, and antithrombotic effects, supported by multiple human RCTs.
• Integumentary system (skin and hair): Used in cosmetology as a moisturizer and to treat devitalized skin; when added to shampoos, the oil penetrates the hair axis and damaged hair follicles, giving hair a fuller and shinier look.
• Endocrine/Metabolic system: Antidiabetic and antihypertensive activity demonstrated in animal models; lipid improvements in type 2 diabetic patients in human studies.
• Hepatic system: Traditional hepatoprotective use; preclinical evidence of reduced hepatotoxicity from xenobiotics.
• Musculoskeletal system: Traditional topical use for joint pain and rheumatological conditions.
• Oncological: In vitro antiproliferative effects on prostate cancer cell lines — no human clinical trial data.
• Gastrointestinal/Microbiome: Preliminary preclinical data on promotion of beneficial gut bacteria.

6. Dosage Forms and Reported Dosages

Therapeutic doses to prevent metabolic diseases range from 15–30 g (1–2 tablespoons) of uncooked argan oil per day.

The following specific dosages have been documented in published clinical studies:

• Cardiovascular risk factors: 15 g/day of argan oil for up to 4 weeks has been used in clinical trials evaluating effects of dietary intake on surrogate markers of cardiovascular disease in healthy subjects. Doses of 25 mL/day to 30 mL/day for 3 to 4 weeks have demonstrated antioxidant activity and improved cholesterol levels in randomized controlled trials.
• Lipid profile study: 25 g/day of virgin argan oil for 3 weeks (intervention period), following a 2-week stabilization period on butter (25 g/day).
• Dyslipidemic diabetic patients: 25 mL/day of argan oil for 3 weeks.
• Skin elasticity/hydration study (postmenopausal women): 25 grams of argan oil per day consumed orally for 60 days, with both groups also applying 10 drops of their assigned oil to a section of the left forearm.
• Skin elasticity study: Dietary argan oil consumed during a 60-day intervention; cosmetic argan oil applied to the left volar forearm concurrently.

Topical dosages in clinical studies have not been standardized. Studies have variously used application of 10 drops to defined forearm areas or incorporation into cream formulations at unspecified concentrations. No standardized topical dosing protocol has been established in the literature reviewed.

7. Safety, Adverse Effects, and Interactions

7.1 General Safety Profile

Formal contraindications have not been identified. Information regarding safety and efficacy in pregnancy and lactation is lacking.

7.2 Allergic Reactions

Research on argan oil has proven beneficial effects on the prevention of cardiovascular diseases, inflammation, atherosclerosis, diabetes, hypertension, and cancer. To date, there is one known case of an allergic reaction to argan oil, which occurred in a 34-year-old Moroccan man.

A 34-year-old Moroccan man without allergy history reported rhinitis and conjunctivitis occurring when he smelled argan oil — the first published case of allergy to argan. The ingestion of argan oil induced epigastralgia and hypersalivation.

To date, only one case of argan oil allergy has been reported in the literature, with digestive manifestations related to argan oil ingestion.

Allergic hypersensitivity reactions, including pneumonitis, have been reported with argan oil and powder. A separate published case documented anaphylaxis following cutaneous application of argan oil (PubMed PMID 32938575). Cases of allergic contact dermatitis caused by argan oil have also been reported in the peer-reviewed literature (PubMed PMIDs 25155076 and 27775969).

7.3 Drug and Nutrient Interactions

No well-documented drug interactions have been identified in the reviewed literature. Given argan oil's demonstrated effects on lipid profiles, platelet aggregation, and antioxidant status in human studies, theoretical pharmacodynamic interactions with anticoagulant, antiplatelet, and lipid-lowering medications cannot be excluded, but these have not been formally studied or documented.

7.4 Evidence Gaps and Overall Assessment

A lack of clinical data constitutes a serious weakness in existing knowledge about argan oil, and it is difficult to correlate reported pharmacological activities to any potential clinical relevance. Limited — though increasing — evidence suggests that argan oil might be endowed with potential healthful properties, mostly in the areas of cardiovascular disease and prostate cancer. Most studies to date are small, of short duration, and conducted predominantly in Moroccan and North African populations, limiting generalizability. Many mechanistic findings come from in vitro or animal experiments, and independent large-scale RCTs in diverse populations are needed to confirm and extend findings.

References

• Gharby S et al. Argan Oil: Chemical Composition, Extraction Process, and Quality Control. Frontiers in Nutrition, 2022. PMC8850956.
• Drissi A et al. Therapeutic potential of argan oil: a review. Phytotherapy Research, 2011. PubMed PMID 21054392.
• Serrafi A et al. The Importance of Argan Oil in Medicine and Cosmetology. Nutrients, 2024. PMC11510224.
• Abdalla S, Aroua MK, Gew LT. A Comprehensive Review of Plant-Based Cosmetic Oils. ACS Omega, 2024. PMC11541506.
• Sahebkar A et al. The impact of argan oil on plasma lipids in humans: Systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research, 2018. PubMed PMID 29130532.
• Derouiche A et al. Argan oil improves surrogate markers of CVD in humans. Nutrition, 2012. PubMed PMID 22082585.
• Drissi A et al. Nutritional intervention study with argan oil in man: effects on lipids and apolipoproteins. Annals of Nutrition & Metabolism, 2004. PubMed PMID 16020940.
• Cherki M et al. Consumption of argan oil may have an antiatherogenic effect by improving paraoxonase activities and antioxidant status: Intervention study in healthy men. Nutrition Metabolism & Cardiovascular Diseases, 2005. PubMed PMID 16216721.
• Drissi A et al. Evidence of hypolipemiant and antioxidant properties of argan oil. Clinical Nutrition, 2004. PubMed PMID 15380909.
• Ould Mohamedou MM et al. Argan Oil Exerts an Antiatherogenic Effect by Improving Lipids and Susceptibility of LDL to Oxidation in Type 2 Diabetes Patients. International Journal of Endocrinology, 2011. PMC3206503.
• Haimeur A et al. Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation. Lipids in Health and Disease, 2013. PMC3751630.
• Berrougui H et al. Antithrombotic activity of argan oil: an in vivo experimental study. Phytotherapy Research, 2012. PubMed PMID 22465906.
• Boucetta KQ et al. The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity. Clinical Interventions in Aging, 2015. PMC4321565.
• Boucetta KQ et al. Skin hydration in postmenopausal women: argan oil benefit with oral and/or topical use. Skin Research and Technology, 2015. PMC4520377.
• Moga MA et al. Preliminary study on the development of an antistretch marks water-in-oil cream. Drug Design, Development and Therapy, 2016. PMC5019162.
• Taghizadeh M et al. Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration. Drug Design, Development and Therapy, 2014. PMC4137996.
• Bennani H et al. Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines. Cancer Detection and Prevention, 2007. PubMed PMID 17174037.
• Drissi A et al. Tocopherols and saponins derived from Argania spinosa exert an antiproliferative effect on human prostate cancer. Cancer Detection and Prevention, 2006. PubMed PMID 16982463.
• Charrouf Z, Guillaume D. Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. Journal of the Science of Food and Agriculture, 2002. PubMed PMID 12548113.
• Naceiri Mrabti H et al. The protective effect of argan oil and its main constituents against xenobiotics-induced toxicities. PubMed PMID 39645052, 2024.
• El Midaoui A et al. Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome: A Preclinical Study. PMC5713458.
• Astier C et al. Anaphylaxis to argan oil. Allergy, 2010. PubMed PMID 19839978.
• Anaphylaxis After Cutaneous Application of Argan Oil. PubMed PMID 32938575, 2020.
• Drugs.com Natural Products Database: Argan Uses, Benefits & Dosage.
• Chakhchar A et al. Ethnobotany, traditional knowledge, and nutritional value of Argan (Argania spinosa) in Western Anti-Atlas of Morocco. PubMed PMID 35544795.
• Britannica: Argan oil | Description, Origin, Uses, History & Facts.
• ScienceDirect: Unveiling the health benefits of argan oil: Bioactive molecules and phytochemical insights for food applications, 2025.
• PMC7570657: Fatty Acid Composition of Cosmetic Argan Oil: Provenience and Authenticity Criteria.