Ingredientes

Aloe vera

Condiciones de Salud63

Tabla de contenidos

Otros Nombres

Sabor Natural de BayasSabor de Bayas MixtasComplejo de Tocoferol (Beta y Delta)Polvo de Jugo de MoraAloe barbadensis var. chinensis Haw.Aloe chinensis LoudonAloe elongata MurrayAloe flava Pers.Aloe humilis BlancoAloe indica RoyleAloe lanzae Tod.Aloe littoralis J.Koenig ex BakerAloe maculata Forssk.Ginseng indiocereza de inviernoAloe rubescens DC.Aceite de AstaxantinaAloe vera var. chinensis (Loudon) BakerRaíz de Áster PúrpuraAster Tataricus (Zi Wan)Extracto de Raíz de ÁsterSabor de Baya SilvestreAloiPolen de Abeja CrudoHuang QiAtractylodes Macrocephala (Bai Zhu)Extracto de Astragalus MembranaceusBurn aloeBurn plantCape aloeChinese aloeRizoma de AtractylodesAtractylodes Lancea (Cang Zhu)Curacoa aloesGránulos de Polen de AbejaDirgha PatraMezcla de Tocoferol No AlfaFirst aid plantExtracto de AgracejoCorteza de AgracejoRaíz de AgracejoSílice de BambúCera de Abeja Blancamirto de ceraExtracto de Polen de AbejaIndian aloeIndian aloesJadamgrano de cebadaCera de Abeja Amarillapasto de cebadaBentonita de CalcioPellets de Cera de AbejaExtracto de Cera de Abejacorteza de raíz de mirto ceríferoMazambronExtracto de BambúMediterranean aloeExtracto de Jugo de RemolachaPolvo de RemolachaArcilla de BentonitaExtracto de Sabor de BayaMezcla Patentada de Hoja de PerillaExtracto de Perilla BeneGut®SábilaSabilaBentonita de SodioExtracto de Hoja de AlbahacaRaíz de AstragaloTocoferoles MixtosHoja de BambúSulfato de BerberinaAlbahaca DulceRemolacha Fermentadanaranja bergamotaaceite esencial de bergamota

Sinopsis

Aloe Vera (Aloe barbadensis Miller)

1. Identity: Botanical Classification, Nomenclature, and Forms

1.1 Scientific and Common Names

The accepted scientific names for the common aloe plant include Aloe barbadensis Miller, Aloe vera L., and Aloe vera Tournefort ex Linné; the synonym Aloe vulgaris Lamarck (also known as Curacao or Barbados aloe) is also encountered in the literature. Other recognized species used commercially include Aloe ferox Miller (Cape aloe) and Aloe perryi Baker (Zanzibar or Socotrine aloe). Common names in English include "aloe vera," "burn plant," and "lily of the desert." In various languages and traditions it has been called Ghee-Kunwar, Hsiang-Dan, Kanya, and Kumari.

1.2 Botanical Description and Natural Source

Aloe vera is one of approximately 420 plant species of the genus Aloe; it is a stemless or very short-stemmed perennial succulent (xerophyte). The whole leaf of Aloe vera is composed of two primary components: the inner gel and the outer leaf latex. The main feature of the whole leaf is its high water content, ranging from 99.0% to 99.5%. However, the remaining 0.5%–1.0% of the plant leaf contains over 75 potentially bioactive ingredients, such as aloin, aloe-emodin, aloe rhein, and aloe polysaccharides.

This herbaceous plant belongs to the Asphodelaceae family, previously classified as Liliaceae. Although Aloe vera originated in the warm, dry climates of Africa, the plant is readily adaptable and grows worldwide. Aloe vera has since spread to many parts of the world through trade and human migration, and is now cultivated in many tropical and subtropical regions including India, Mexico, China, South America, Spain, and Italy.

1.3 Plant Anatomy: Gel vs. Latex

Aloe products can be made from various parts of the aloe leaf, including the gel (from the inner leaf), latex (from the leaf's outer layer), and whole crushed leaf (containing both the gel and latex). These two fractions—gel and latex—have fundamentally different chemical compositions and safety profiles. The inner colorless gel is the basis for most topical and many oral preparations; the yellow-green latex (also called "aloe juice" or "dried aloe" in older texts) is located in the cells just beneath the outer green rind and contains the anthraquinone glycosides responsible for cathartic activity.

1.4 Common Preparations and Dosage Forms

Commercial topical forms include topical cream, topical gel, topical liquid, topical lotion, topical soap, topical spray, and mucous membrane preparations for oral wound rinse. Oral preparations include raw gel, juice, capsules, tablets, and powdered extracts. Use of Aloe vera gel extracts in health foods and beverages and moisturizing cosmetics began during the 1970s, starting in the USA and parts of Europe. In Western society, Aloe vera is one of the few herbal medicines in common usage, and it has found widespread use in the cosmetic, pharmaceutical, and food industries.

2. Traditional and Historical Use

2.1 Earliest Documented Records

The first record of human use of Aloe vera is in Sumerian hieroglyphics engraved on clay tablets during the Mesopotamia civilization circa 2200 BC, in which it is described as a laxative. Use of aloe in ancient times is also documented in Egypt, Greece, and China.

Aloe vera, known as the "plant of immortality" in early Egypt, has been used as a traditional medicine in Arab, Chinese, Egyptian, Greek, Indian, Japanese, Korean, and Roman cultures for more than 2000 years to empirically treat a broad list of disorders and ailments, such as skin problems (wounds, X-ray and radium burns, and psoriasis), constipation, external and internal ulcers, hyperlipidemia, diabetes, and lupus erythematosus.

2.2 Ancient Egypt and the Mediterranean World

Aloe vera has been used for medicinal purposes in several cultures for millennia — Greece, Egypt, India, Mexico, Japan, and China. Egyptian queens Nefertiti and Cleopatra used it as part of their regular beauty regimes. Alexander the Great and Christopher Columbus used it to treat soldiers' wounds. Aloe vera was also used in ancient times to embalm the dead, as well as to protect embalmers from pathogens. Other early civilizations used it for skin care, to relieve insect stings and bites, to treat scratches and ulcerated skin, to promote wound healing, to prevent hair loss, and as a purgative.

Greek botanist Dioscorides, in his De Materia Medica (circa 40–90 CE), recorded its use for burns, stomach issues, and more, highlighting the wide range of applications of aloe vera in traditional medicine.

2.3 Traditional Indian Medicine (Ayurveda)

It is used in traditional Indian medicine for constipation, colic, skin diseases, worm infestation, and infections. In India, Ayurvedic healers called it "kumari" (meaning "princess" for its renewing qualities) and used it for skin issues, menstrual problems, and digestion. In Ayurveda, Aloe vera is revered as the "wand of heaven" or "heaven's blessing" and precisely the "silent healer."

2.4 Traditional Chinese Medicine

In Traditional Chinese Medicine (TCM), Aloe vera is acknowledged for its abundant bioactive substances that have considerable therapeutic value. In ancient China, aloe vera — called "lu hui" — was used for skin conditions and constipation. In Chinese medicine, it is often recommended in the treatment of fungal diseases.

2.5 Other Cultures and Traditions

It is also used in Trinidad and Tobago for hypertension and among Mexican Americans for the treatment of type 2 diabetes mellitus. It was the traditional medicine of many cultures as an anthelmintic, cathartic, and stomachic, and was used for leprosy, burns, and allergic conditions.

2.6 Introduction to the Caribbean and North America

Aloe vera was cultivated on the islands of Barbados and Curaçao in the Caribbean by Spain and the Netherlands, and was sold in various parts of Europe during the 17th century. Commercial cultivation of Aloe vera in the USA began in the 1920s in Florida. Aloe vera first gained popularity in the USA in the 1930s with reports of successful use of freshly cut leaves in treating X-ray burns.

3. Key Constituents and Active Compounds

Aloe vera contains several bioactive compounds, including polysaccharides, vitamins, minerals, enzymes, and amino acids, each contributing to its therapeutic effects. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan.

3.1 Polysaccharides (Including Acemannan)

The mucopolysaccharides are derived from the mucilage layer of the plant. The most prominent monosaccharide is mannose-6-phosphate, and the most common polysaccharides are called glucomannans [beta-(1,4)-acetylated mannan]. Acemannan, a prominent glucomannan, has also been identified.

Acemannan (AC) is considered to be a natural polysaccharide with good biodegradability and biocompatibility extracted from Aloe vera; it has a wide range of applications in the biomedical field due to excellent immunomodulatory, antiviral, antitumor, and tissue regeneration effects. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others.

Acemannan is a strong plant-based immunomodulator that controls various immunological reactions and has various pharmacological roles in combination with other bioactive compounds. Acemannan acts as a modulator of the immune system by increasing macrophage cytokine production, expression of surface markers, and nitric oxide release. Many of the health benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. These biological activities include promotion of wound healing, antifungal activity, hypoglycemic or antidiabetic effects, anti-inflammatory properties, anticancer effects, immunomodulatory properties, and gastroprotective properties.

3.2 Anthraquinones

Aloe vera provides 12 anthraquinones, which are phenolic compounds traditionally known as laxatives. Aloin and emodin act as analgesics, antibacterials, and antivirals. Aloin is converted by gut bacteria to aloe-emodin, which stimulates colonic motility and fluid secretion, producing the laxative effect. The well-established cathartic properties of anthraquinone glycosides provide strong evidence in support of the laxative properties of Aloe vera.

3.3 Phytosterols (Fatty Acids)

Aloe vera provides 4 plant steroids: cholesterol, campesterol, β-sitosterol, and lupeol. All of these have anti-inflammatory action; lupeol also possesses antiseptic and analgesic properties.

3.4 Hormones

Auxins and gibberellins present in Aloe vera help in wound healing and exert anti-inflammatory action.

3.5 Glycoproteins and Other Phenolic Compounds

A glycoprotein with antiallergic properties, called alprogen, and a novel anti-inflammatory compound, C-glucosyl chromone, have been isolated from Aloe vera gel. Aloe vera also contains salicylic acid, which possesses anti-inflammatory and antibacterial properties. Lignin, an inert substance, when included in topical preparations, enhances the penetrative effect of the other ingredients into the skin. Saponins, the soapy substances, form about 3% of the gel and have cleansing and antiseptic properties.

While the polysaccharides present in the inner gel — particularly acemannan — have been credited for many of the therapeutic effects of Aloe vera, other constituents such as lectins, alkaloids, anthraquinones, anthrones, chromones, coumarins, and polyphenols also contribute to its diverse and numerous benefits.

3.6 Amino Acids and Nutrients

Aloe vera gel provides 20 of the 22 human-required amino acids and 7 of the 8 essential amino acids.

4. Scientific Evidence by Area of Use

Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because of its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. Most recent works are in vitro and in vivo. Clinical trials have been conducted only with Aloe vera whole preparations, and not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies.

4.1 Skin: Burns and Wound Healing

Clinical evidence: Aloe vera has been traditionally used for burn healing, but clinical evidence has remained unclear. A systematic review was conducted to determine the efficacy of topical aloe vera for the treatment of burn wounds. Four studies with a total of 371 patients were included in this review. Based on a meta-analysis using duration of wound healing as an outcome measure, the summary weighted mean difference in healing time in the aloe vera group was 8.79 days shorter than those in the control group (P = 0.006).

Due to the differences in products and outcome measures, there is paucity of evidence sufficient to draw a specific conclusion regarding the effect of aloe vera on burn wound healing. However, cumulative evidence tends to support that aloe vera might be an effective intervention in burn wound healing for first- to second-degree burns. Further, well-designed trials with sufficient detail on the contents of aloe vera products should be carried out to determine its effectiveness.

In a systematic review of 23 clinical trials meeting inclusion criteria, the results showed that Aloe vera has been used to prevent skin ulcers and to treat burn wounds, postoperative wounds, cracked nipples, genital herpes, psoriasis, and chronic wounds including pressure ulcers.

Five studies specifically investigated burn wound healing. In these studies, Aloe vera was more effective than petroleum jelly gauze dressing, silver sulfadiazine 1% ointment, and framycetin cream.

Evidence limitations: Collectively, there is little high-level evidence to support the use of Aloe vera topical agents or aloe-derived dressings in the treatment of acute and chronic wounds. There is currently insufficient clinical trial evidence available regarding the effects of Aloe vera topical agents or dressings as treatments for acute and chronic wounds. This is primarily due to the lack of high-quality trials with adequate methodology. The measurement of outcomes was subjective, and clinicians were, in general, not blinded to intervention category, thereby introducing the possibility of measurement bias.

Overall, clinical research suggests topical application of aloe gel may speed burn healing and reduce burn-related pain. Whether it promotes wound healing more broadly is unclear.

4.2 Skin: Psoriasis, Lichen Planus, and Other Dermatological Conditions

A small amount of research suggests topical use of aloe also may help people with genital herpes, lichen planus, psoriasis, oral submucous fibrosis, skin damage from radiation therapy, or sores in the mouth from dental appliances.

Aloe gel has been studied as a topical treatment for oral lichen planus, with some studies demonstrating reduced pain, burning sensation, and clinical improvement compared to placebo. While the evidence is more consistent here than for some other indications, the studies remain small and additional research is needed. One systematic review and meta-analysis examining the effect of topical aloe vera in clinical improvement in those with symptomatic oral lichen planus found weak evidence that aloe vera is more efficient than placebo in the treatment of oral lichen planus but results were described as promising, especially since it has no adverse effects.

Topical aloe vera's application to radiation-induced skin injury has been studied: Topical application of aloe vera is not an effective preventive for radiation-induced injuries.

Topical aloe appears to inhibit infection and promote healing of minor burns and wounds, frostbite, striae gravidum, and skin affected by diseases such as psoriasis and seborrheic dermatitis, although studies have had conflicting results.

4.3 Gastrointestinal System: Constipation and Laxative Use

The World Health Organization (WHO) lists the short-term treatment of occasional constipation as a use for Aloe vera latex that is supported by clinical data. In 2002, the US Food and Drug Administration (FDA) issued a final rule stating that use of Aloe as a nonprescription laxative drug is no longer generally recognized as safe and effective. In 2002, the U.S. Food and Drug Administration issued a ruling that required manufacturers to remove aloe latex from over-the-counter laxative products because of a lack of safety data.

4.4 Gastrointestinal System: Gastroesophageal Reflux Disease (GERD)

A review by Mahboubi (2021) summarizes studies regarding the effectiveness of Aloe vera gel in the management of GERD. It comprises five clinical studies in patients suffering from GERD treated with 10 mL of Aloe vera gel syrup twice daily, in comparison to omeprazole, ranitidine, pantoprazole, or aluminum–magnesium hydroxide. It was found that Aloe vera gel syrup significantly eliminated GERD symptoms without any adverse effects, when compared with omeprazole or ranitidine. This preparation was found to be safe and well tolerated, reducing the frequencies of all assessed GERD symptoms, with no side events requiring withdrawal.

4.5 Gastrointestinal System: Irritable Bowel Syndrome (IBS) and Ulcerative Colitis

In a 3-month randomized controlled trial of 58 patients with irritable bowel syndrome, no evidence was found to suggest that Aloe vera has any beneficial effect.

A randomized controlled trial of 44 subjects with mild to moderately active ulcerative colitis produced encouraging, although not conclusive, results. The oral administration twice daily of 100 mL of Aloe vera gel to 30 subjects for 4 weeks generated clinical remission and improvement.

There is interest in using aloe for many other conditions, but there isn't enough reliable information to say whether it might be helpful for those conditions, which include eczema, diabetic foot ulcers, irritable bowel syndrome, and ulcerative colitis.

4.6 Metabolic Health: Diabetes and Blood Glucose

Clinical evidence: A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials identified a total of five randomized controlled trials (RCTs) involving 415 participants. Compared with controls, aloe vera supplementation significantly reduced the concentrations of fasting blood glucose (FBG) (p = 0.02; weighted mean difference [WMD]: −30.05 mg/dL; 95% CI: −54.87 to −5.23 mg/dL), glycosylated hemoglobin A1c (HbA1c) (p < 0.00001; WMD: −0.41%; 95% CI: −0.55% to −0.27%), triglyceride, total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C). Aloe vera was superior to placebo in increasing serum high-density lipoprotein-cholesterol (HDL-C) levels (p = 0.04).

Evidence presented in multiple supported clinical trials proved a mean reduction in HbA1c of −0.99% (95% CI: −1.75, −0.23) with Aloe vera leaf gel, placing it at the top of the most efficient natural remedies for long-term glycemic regulation in type 2 diabetes mellitus.

One double-blind RCT in pre-diabetic subjects used capsules twice daily in three groups: Aloe vera 300 mg (AL300), 500 mg (AL500), and placebo (PL). Fasting blood glucose (FBS), HbA1c, and lipid profile were evaluated at baseline, 4 weeks, and 8 weeks.

Evidence limitations: The results of systematic reviews are controversial. Two systematic reviews supported the use of oral aloe vera for significantly reducing fasting blood glucose, and the other two showed limited evidence for the effectiveness of oral and topical aloe vera. The effects are not sufficiently defined, and the inconsistent results of previous systematic reviews indicate that the results must be interpreted with caution. The available meta-analyses suggest that Aloe vera has a therapeutic and consistent effect on glycemic control, but short-term FBG was markedly influenced by the variations of prevention protocols. Therefore, prolonged HbA1c reduction is consistently promising, emphasizing the need for further clinical trials to implement standardized preparations, stable and steady doses, and surveillance periods longer than 8 weeks.

A small amount of research suggests that aloe taken orally may reduce blood sugar and HbA1c in people with diabetes. A small study showed that a specific aloe gel product taken orally for 8 weeks modestly reduced weight and fat mass in adults with obesity or overweight who had diabetes or prediabetes.

4.7 Oral Health: Oral Submucous Fibrosis and Dental Applications

Aloe vera extract (50%) increased cell viability of dental pulp stem cells, which may be useful for avulsed broken teeth. This effect is attributed to polysaccharides, mainly acemannan, by inducing osteogenic-specific gene expressions, DNA synthesis, growth factor, and JAK-STAT pathway activation.

Topical aloe vera gel was applied to the oral mucosa 3 times daily for 3 months in a study of oral submucous fibrosis. Burning sensation (P = 0.001), mouth opening (P = 0.004), and tongue protrusion (P = 0.001) were improved significantly in the topical aloe group compared to the oral antioxidant comparator.

4.8 Immune Modulation and Anticancer Research

New pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. The two fractions from aloe claimed to have anti-cancer effects include glycoproteins (lectins) and polysaccharides. The anti-tumour activity of polysaccharides isolated from Aloe vera and specifically acemannan has been investigated in many in vitro models as well as in different animal species. Different studies have indicated anti-tumour activity for Aloe vera gel in terms of reduced tumour burden, tumour shrinkage, tumour necrosis, and prolonged survival rates.

The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes. It is important to note that anticancer evidence for Aloe vera in humans is, as of the most recent reviews, predominantly limited to in vitro and animal models; robust human clinical trial data are lacking.

4.9 Acne

Two small studies suggest that topical application of aloe gel, in combination with other forms of treatment, may improve acne.

5. Body Systems and Health Areas Associated with Aloe Vera

Integumentary system (skin): Burns, wound healing, psoriasis, seborrheic dermatitis, lichen planus, genital herpes, acne, radiation dermatitis, oral submucous fibrosis, frostbite.
Gastrointestinal system: Constipation (latex/anthraquinone action), GERD, irritable bowel syndrome, ulcerative colitis, peptic ulcer.
Endocrine/metabolic system: Blood glucose regulation, lipid profile improvement in pre-diabetes and type 2 diabetes.
Immune system: Immunomodulation (primarily via acemannan), potential antiviral and antimicrobial effects.
Oral/dental: Gingivitis, lichen planus of the mouth, oral mucositis, dental pulp cell viability.

Conditions for which some scientific evidence exists include seborrheic dermatitis, psoriasis vulgaris, genital herpes, skin burns, diabetes (type 2), HIV infection, cancer prevention, ulcerative colitis, wound healing (with mixed results), pressure ulcers, mucositis, radiation dermatitis, acne vulgaris, lichen planus, frostbite, aphthous stomatitis, and constipation.

6. Dosage Forms and Dosages Reported in Clinical Studies

There is no established standard dose for aloe vera, as the appropriate amount depends on the form, preparation method, and intended use.

Oral aloe vera gel for GERD: Ten mL of Aloe vera gel syrup twice daily, studied in five clinical trials against standard pharmacological comparators.
Oral aloe vera gel for ulcerative colitis: 100 mL of Aloe vera gel administered orally twice daily for 4 weeks in 30 subjects in one RCT.
Oral capsules for metabolic syndrome/blood sugar: 500 mg twice daily for 8 weeks has been reported as a dosage studied in metabolic syndrome trials.
Oral capsules for pre-diabetes: Aloe vera 300 mg and 500 mg capsules twice daily were studied in a double-blind RCT of 72 subjects with pre-diabetic symptoms.
Topical gel for oral submucous fibrosis: Topical aloe vera gel was applied to the oral mucosa 3 times daily for 3 months.
Topical preparations for burns: Various clinical trials have employed aloe vera gel, cream, or derivatives that included a control group with placebo or comparison with other treatments. Specific concentrations and formulations varied across trials.
Oral safety data: Research studies suggest that short-term use of oral aloe gel up to 42 days is safe.

7. Safety Considerations and Drug Interactions

7.1 Gel vs. Latex: Distinct Safety Profiles

The inner leaf gel and outer leaf latex have distinct properties and very different safety profiles. While aloe gel is generally safe and shows preliminary benefits for GERD, blood sugar, and topical skin conditions, aloe latex carries significant risks including potential carcinogenicity. Understanding the difference between gel and latex is critical for safe use.

7.2 Adverse Effects of Oral Aloe Preparations

Ingestion of Aloe preparations is associated with diarrhea, hypokalemia, pseudomelanosis coli, kidney failure, as well as phototoxicity and hypersensitive reactions. Oral use of aloe latex can cause abdominal pain, cramps, and diarrhea. Oral consumption of aloe leaf extracts (for as little as 3 weeks and as long as 5 years) has been related to cases of acute hepatitis.

Taking 1 g a day of aloe latex for several days can cause kidney damage and might be fatal. There have been a few case reports of acute hepatitis from this product when taken orally, although evidence is not definitive.

7.3 Carcinogenicity Classification

Aloe vera whole leaf extract showed clear evidence of carcinogenic activity in rats and was classified by the International Agency for Research on Cancer as a possible human carcinogen (Group 2B). This review presents updated information on the toxicological effects, including the cytotoxicity, genotoxicity, carcinogenicity, and adverse clinical effects of Aloe vera whole leaf extract, gel, and latex.

The International Agency for Research on Cancer has classified whole leaf extract of Aloe vera as a possible human carcinogen. This form, called non-decolorized, has not undergone activated carbon treatment to remove toxic anthraquinone components. Some animal studies have noted an association between a non-decolorized extract of aloe vera leaf taken orally and gastrointestinal cancer in rats and mice; most toxicity and safety studies in animals have tested non-decolorized whole leaf extract of aloe vera, which is not commonly used by consumers.

Due to its widespread human exposure and concerns that some components may cause cancer, in 1998 the National Cancer Institute nominated Aloe vera as a high-priority candidate for a carcinogenicity study under the National Toxicology Program (NTP).

7.4 Topical Safety

Topical use of aloe gel is generally well tolerated; however, there have been occasional reports of burning, itching, rash, and eczema. Topical aloe preparations are not recommended for treating deep vertical wounds: Aloe vera gel has been shown to delay wound healing in cases of surgical wounds such as those produced during laparotomy or cesarean delivery.

7.5 Populations Requiring Particular Caution

The oral use of aloe latex and whole-leaf extracts is possibly unsafe for children, as it may cause abdominal pain, cramps, and diarrhea in children under 12 years of age. During pregnancy, oral use of aloe is considered possibly unsafe due to the presence of irritant, cathartic, and potential mutagenic effects of anthraquinones found in aloe latex and whole-leaf extracts. Anecdotal reports and animal research suggest that these substances may induce abortion and stimulate menstruation. For lactating individuals, the oral use of aloe preparations is possibly unsafe. Cathartic and mutagenic anthraquinones present in aloe latex and whole-leaf extracts might pass into breast milk.

Due to the irritating effect of its anthranoid aloins, aloe dried juice/latex should not be used by individuals with intestinal obstruction, Crohn's disease, ulcerative colitis, appendicitis, peptic ulcers, abdominal pain of unknown origin, nausea, vomiting, hemorrhoids, or kidney disease.

7.6 Drug Interactions

Due to the hypoglycemic effects of internally consumed Aloe vera gel, persons using glyburide drugs to control blood sugar (e.g., Diabeta, Micronase, Glynase) should monitor blood glucose levels closely. Orally administered aloe dried juice/latex causes a shorter gastrointestinal transit time and may reduce the absorption of some drugs.

When taken orally for prolonged periods with diuretics or digoxin, aloe can lead to low blood levels of potassium (hypokalemia) due to diarrhea. When combined with sevoflurane, an inhaled general anesthetic used in surgery, aloe vera may cause excessive bleeding due to its anti-platelet effect. It increases the effects of the blood thinner warfarin and can cause excessive bleeding.

Potential for adverse effects exists when aloe dried juice/latex is used excessively along with herbs containing cardiac glycosides (e.g., black hellebore, Canadian hemp roots, digitalis leaf, pheasant's eye plant, pleurisy root, squill bulb leaf scales, and strophanthus seeds) or with other cardiac medications.

References

Condiciones de Salud

Condiciones de salud que Aloe vera puede ayudar a apoyar.

DislocaciónCientífico
Aloe vera has been investigated in clinical trials for IBS-related abdominal discomfort, with mixed but supportive results. It is listed among botanicals studied for IBS management in peer-reviewed systematic reviews. Traditional use for digestive upset spans thousands of years across multiple cultures.
AbrasionesCientífico
A 2015 pilot RCT (n=79) compared aloe vera gel syrup (10 mL/day) to omeprazole and ranitidine over 4 weeks, finding it reduced all eight assessed GERD symptoms with no adverse events requiring withdrawal, with efficacy comparable to standard drugs. A 2021 review of five clinical studies concluded aloe vera gel syrup consistently reduced GERD symptoms. Mechanisms include reduction of gastric acid secretion, anti-inflammatory cytokine modulation, and mucosal protection by polysaccharides.
AbscesosCientífico
Aloe vera gel has been used topically for acne as a traditional wound-healing and anti-inflammatory agent, and has been validated in clinical trials. A 2022 systematic review of herbal medicine RCTs for acne (34 trials, 1,753 participants) found aloe vera significantly reduced total acne lesion counts compared to placebo. A propolis–tea tree oil–aloe vera combination was also shown in two double-blind RCTs to outperform erythromycin cream.
DisenteríaCientífico
A prospective double-blind clinical trial (Rahmani et al., 2014, Eur Rev Med Pharmacol Sci) found topical 0.5% aloe vera juice cream applied 3×/day for 6 weeks produced statistically significant reductions in chronic anal fissure pain, bleeding on defecation, and wound healing scores vs. control (p<0.0001). A rat-model study also showed aloe vera extract significantly reduced the residual fistula tract area compared to controls. Systematic reviews confirm aloe vera promotes epithelialization and collagen deposition relevant to anorectal wound healing.
HipocondríaCientífico
Aloe vera is rich in polyphenols, flavonoids, and anthraquinones with documented antioxidant activity. Phosphorylated aloe vera polysaccharides have in vitro antioxidant activity equivalent to vitamin C. Aloe vera administration in animal models restores depleted hepatic glutathione (GSH) and reduces malondialdehyde (MDA), markers of oxidative stress.
EccemaCientífico
Aloe vera gel has been evaluated for osteoarthritis and inflammatory arthritis pain, showing anti-inflammatory activity via suppression of TNF-α and COX-2 gene expression in animal models. Oral aloe vera has been studied for chronic non-cancer pain including osteoarthritis. Traditional use in Ayurveda for arthritis pain is longstanding.
Adicciones (café, cafeína)Científico
Aloe vera extracts demonstrate in vitro antifungal activity against dermatophytes including Trichophyton rubrum, the primary causative agent of tinea pedis. One randomized double-blind study found a 70% aloe cream produced a 70% cure rate for tinea pedis after six weeks versus placebo. Evidence is present but limited in scale; aloe is not a guideline-recommended primary antifungal.
Adicciones (azúcar o carbohidratos refinados)Científico
Aloe vera mouthwash has been evaluated in clinical trials for its antibacterial and anti-inflammatory effects in the oral cavity, which are relevant to halitosis reduction. Its antiseptic constituents (salicylic acid, lupeol, sulfur-containing agents) suppress oral bacteria responsible for volatile sulfur compound production. It has also shown efficacy against oral candidiasis, a contributing factor to oral malodor.
Adicciones (tabaquismo o masticación de tabaco)Científico
Aloe vera gel has been used since antiquity by multiple civilizations—including ancient Egyptians—to relieve insect stings and bites. Modern research documents anti-inflammatory, antimicrobial, and wound-healing bioactives (polysaccharides, glycoproteins, anthraquinones). Multiple in vitro and animal studies confirm reduction of inflammation and promotion of skin healing; limited human trials suggest relief of pain, swelling, and itching.
AdenitisCientífico
Aloe vera gel has been used traditionally and studied clinically for skin wound healing, including blister management. A 2024 clinical trial (BMC Research Notes) found that aloe vera gel dressing preserved blister membrane integrity and reduced pain in pressure ulcer patients compared to conventional dressing. A Cochrane systematic review and multiple other reviews confirm its anti-inflammatory, epithelialization-accelerating, and soothing properties for acute skin wounds.
Fatiga SuprarrenalCientífico
Aloe vera gel has demonstrated blood glucose-lowering effects in multiple RCTs in prediabetic and early-stage diabetic patients. A meta-analysis of 5 RCTs (415 participants) found aloe vera significantly reduced FBG by 30 mg/dL and HbA1c by 0.41% versus placebo. It also improved lipid profiles.
Enfermedad de AlzheimerCientífico
Multiple systematic reviews and controlled clinical trials support topical aloe vera gel for partial-thickness burns, showing statistically significantly faster healing times and higher rates of complete healing compared to silver sulfadiazine and other comparators. A meta-analysis (Burns, 2022) found the mean time to wound healing significantly favored aloe vera (RR: -1.34, 95% CI: -1.8 to 0.9, p<0.001). Level 1 evidence also indicates pain relief in partial-thickness burn wounds.
AnemiaCientífico
Aloe Vera gel has been evaluated in multiple randomized controlled trials for recurrent aphthous stomatitis (RAS). In a landmark double-blind RCT (Mansour et al., J Oral Pathol Med 2014), a 0.5% aloe vera mucoadhesive gel produced complete ulcer healing in 76.6% of patients and subsidence of erythema in 86.7% by day 6. A 2024 systematic review and meta-analysis of RCTs confirmed that aloe vera significantly reduces pain and promotes healing in oral ulcers.
Válvula IleocecalCientífico
A systematic meta-analysis of five RCTs (n=415) found aloe vera supplementation significantly reduced total cholesterol and LDL-C, and increased HDL-C in pre-diabetic and early diabetic patients. A 12-week controlled trial in 60 hyperlipidemic patients using whole-leaf extract also showed significant decreases in total cholesterol and LDL.
ApendicitisCientífico
Aloe vera contains bioactive compounds (acemannan, aloe-emodin, aloesin, emodin, aloin) shown to suppress key inflammatory mediators including IL-6, TNF-α, iNOS, and COX-2 via NF-κB and MAPK pathway downregulation. Both in vitro and in vivo evidence supports anti-inflammatory activity. A 2025 review highlights its potential against chronic inflammaging-driven conditions.
Disfunción EréctilCientífico
Aloe vera has antiviral, anti-inflammatory, and wound-healing properties documented in laboratory, animal, and limited clinical studies for herpes infections. Compounds including acemannan inhibit HSV-1 replication. A double-blind RCT (Phytomedicine 1999) found 0.5% aloe extract cream improved healing in genital herpes. Animal studies confirmed delayed blister progression in HSV lesions. Evidence for herpes labialis specifically is more limited than for genital herpes.
Estrógeno (bajo)Científico
A double-blind, placebo-controlled RCT demonstrated that oral aloe vera gel (100 ml twice daily for 4 weeks) induced clinical remission in active ulcerative colitis patients, outperforming placebo. In vitro studies show aloe gel reduces prostaglandin E2 and IL-18 secretion in colonic mucosa, supporting anti-inflammatory activity.
EjercicioCientífico
Aloe vera latex contains anthraquinone glycosides (primarily aloin) that stimulate colon peristalsis and increase fluid secretion, traditionally used as a purgative for colon cleansing. The laxative effect is well-established by NIH/NCCIH and other authoritative sources, though FDA removed aloe latex from OTC laxatives in 2002 citing safety data gaps. Aloe gel (decolorized) is used for its soothing mucosal properties.
ArtritisCientífico
Aloe vera latex contains anthraquinone glycosides (aloin/barbaloin) with well-established stimulant laxative properties. The German Commission E approved aloe latex preparations for short-term constipation. A double-blind RCT found aloin had a stronger laxative effect than phenolphthalein. The FDA withdrew OTC approval in 2002 pending additional safety data.
Ojos (rojos o con picazón)Científico
Acemannan, aloe vera's primary polysaccharide, was studied in an exploratory clinical pilot in inflammatory bowel disease including Crohn's disease. Animal studies demonstrate aloe vera extract significantly reduces colonic inflammation markers (TNF-α, IL-6, nitric oxide) and improves histopathology in TNBS-induced colitis models.
Pie de atletaCientífico
A double-blind, placebo-controlled RCT (n=44 adults) found that a 30% crude Aloe vera emulsion significantly reduced scalp scaling (36.6% vs. 17.6% placebo) and itching (21.5% vs. 5.3%) in seborrheic dermatitis over 4 weeks. Dermatologist-assessed global improvement was 58% (aloe) vs. 15% (placebo; p=0.009). In vitro studies confirm antifungal activity of aloe vera against Malassezia furfur.
Vista (deficiente)Científico
Aloe vera has been studied for atopic and radiation-induced dermatitis. Systematic reviews and clinical trials have investigated its topical application for radiation dermatitis prevention, with some positive signals; evidence for atopic dermatitis is mixed. Its polysaccharides exhibit anti-inflammatory and barrier-supportive properties.
AutismoCientífico
Aloe vera has been evaluated in multiple randomized clinical trials for diaper dermatitis. A 2012 RCT (Panahi et al., ScientificWorldJournal, PMC3346674) in 66 infants showed significant reduction in severity (p<0.001). A 2024 meta-analysis (n=214) confirmed a meaningful reduction in diaper dermatitis scores after topical aloe application.
Enuresis nocturnaCientífico
Multiple clinical trials have evaluated aloe vera for xerostomia. A triple-blind RCT in 105 diabetic patients (Badooei et al., 2021) found that a 20 mL aloe vera mouthwash used three times daily for 14 days significantly reduced all xerostomia symptoms compared to saline. A separate triple-blind RCT in ICU patients found an aloe vera/peppermint gel (Veramin) significantly reduced mouth dryness and improved oral health.
EructosCientífico
Aloe vera gel is traditionally used across multiple cultures for dry, irritated skin and scientifically confirmed to improve skin hydration. In vivo studies show topical aloe increases skin moisture and reduces TEWL via its mucilaginous polysaccharide acemannan. Clinical research also demonstrates aloe extract upregulates aquaporin-3, the water channel responsible for stratum corneum hydration.
Parálisis de BellCientífico
Topical aloe vera has demonstrated anti-inflammatory, antimicrobial, and barrier-repair properties relevant to eczema. Clinical studies show reductions in SCORAD eczema severity scores with aloe vera cream use. A 2020 trial found a combination including aloe vera gel outperformed a topical corticosteroid (Betamethasone) for atopic dermatitis rashes. Evidence is strongest for mild to moderate disease.
FatigaCientífico
Aloe vera demonstrates documented antifungal activity against dermatophytes (Trichophyton species) and Candida species in vitro, mediated by anthraquinones (aloe-emodin, barbaloin) and a 14 kDa antifungal protein. Aloe vera gel has shown clinical efficacy against oral candidiasis. It is also used as a penetration enhancer in antifungal product formulations.
Enfermedad del Hígado GrasoCientífico
Aloe vera gel possesses antimicrobial, anti-inflammatory, and mucosal-healing properties relevant to gastritis. Clinical trials show aloe vera reduces symptoms of gastric irritation, and animal studies confirm protection against alcohol-induced gastric mucosal damage. It is recognized in integrative medicine protocols for gastritis.
Bultos en el SenoCientífico
Aloe vera gel has been studied as an adjunct to non-surgical periodontal therapy, demonstrating antibacterial activity against key periodontal pathogens including Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Subgingival injection of aloe vera gel has been shown to enhance periodontal health outcomes. A 2021 systematic review included aloe vera among antioxidant therapies significantly improving periodontal parameters in type 2 diabetic patients.
Leche materna (secar)Científico
Aloe vera polysaccharides, particularly acemannan, improve gut mucosal integrity and modulate gut microbiota composition. Acemannan is digested in the colon by microbes into short-chain fatty acids, conferring prebiotic-like benefits. Research also shows aloe may influence gut microbiota in type 2 diabetes models.
FiebreCientífico
Aloe vera has demonstrated in vitro stimulation of dermal papilla cell proliferation (~25%) and has been studied in hair loss RCTs as part of herbal combinations. A 2025 systematic review of 16 RCTs identified aloe vera among natural products with promising clinical efficacy for promoting hair growth. It also has a long traditional use in Ayurveda and folk medicine for scalp and hair health.
BursitisCientífico
Aloe Vera is widely used topically in gels, creams, and suppositories for hemorrhoids. A 2025 PMC comprehensive review reports that aloe preparations improve pain scores and healing time in combination with standard hemorrhoidal therapies, and lists aloe vera among botanical agents demonstrating anti-inflammatory, venotonic, and astringent effects addressing hemorrhoid symptoms.
Síndrome de FibromialgiaCientífico
Topical 0.5% aloe vera extract cream showed significantly improved healing of first-episode genital herpes (HSV-2) lesions in two small placebo-controlled studies in men. In vitro, aloe vera extract reduced HSV-2 cytopathic effects in Vero cells. Evidence is preliminary and primarily applicable to topical use for genital herpes in men.
Tratamiento del Cáncer (reducción de efectos secundarios)Científico
Aloe vera contains aloesin, which inhibits tyrosinase, tyrosine hydroxylase, and DOPA oxidase. A single RCT found that aloesin effectively treats UVR-induced pigmentation independently and synergistically with arbutin (combined efficacy 63.3% melanin reduction). Aloe vera is also identified in systematic reviews as a natural depigmenting agent.
PulgasCientífico
Aloe vera has been evaluated in several IBS-specific RCTs, with a 2025 umbrella review (Nutr Rev, 175 trials) confirming it improved IBS symptoms alongside peppermint oil and soluble fiber. A 2006 double-blind RCT (Davis et al., Int J Clin Pract) and a randomized crossover study (Hutchings et al., ISRN Gastroenterol 2011) both assessed aloe vera specifically in IBS patients. Mechanisms include anti-inflammatory effects on the gut mucosa and mild laxative activity.
FlotadoresCientífico
Aloe vera gel has been studied in small RCTs for ulcerative colitis, with one placebo-controlled trial showing superiority over placebo for inducing remission. A 2013 systematic review of herbal therapies in IBD identified aloe vera gel as superior to placebo in UC. It has anti-inflammatory and immunomodulatory properties relevant to IBD pathophysiology.
Olor de piesCientífico
A systematic meta-analysis of five RCTs in 415 pre-diabetic and early diabetic patients showed aloe vera significantly reduced fasting blood glucose (WMD: −30.05 mg/dL) and HbA1c (WMD: −0.41%). Proposed mechanisms include increased insulin sensitivity in peripheral cells and enhancement of pancreatic beta-cell insulin genetics activity.
Daño por Radicales LibresCientífico
Aloe vera is among the most widely used natural supplements for IC; it is rich in GAG-like polysaccharides that may restore the bladder mucosal lining. Survey and open-label studies report 87.5–92% patient response rates. A formal FDA-approved double-blind RCT (NCT04734106, Wake Forest University) is underway to rigorously assess efficacy.
Vesícula Biliar (perezosa o extirpada)Científico
Aloe vera inner leaf gel contains acemannan (a polysaccharide) and other bioactive compounds that support gut-barrier repair, stimulate mucin secretion, and exert anti-inflammatory effects on the intestinal lining. A 2019 clinical study published in ScienceDirect incorporated aloe vera in a gut-relief herbal formula and found improvements in GI symptoms in Australian adults with digestive disorders. Traditional use for GI conditions spans thousands of years across multiple cultures.
Conmociones cerebralesCientífico
Aloe vera mouthwash has been evaluated in multiple RCTs for its ability to reduce periodontal pathogens and modulate the oral microbial environment. It demonstrates antibacterial activity against Streptococcus mutans, E. faecalis, and periodontal pathogens, and antifungal activity against oral Candida. In a 30-day RCT (270 patients), aloe vera mouthwash reduced plaque and gingival inflammation comparably to chlorhexidine.
Dolor de cabeza (en racimos)Científico
Topical aloe vera (0.5% cream) has been evaluated in multiple RCTs for plaque psoriasis. A landmark double-blind, placebo-controlled trial in 60 patients showed significantly reduced PASI scores with aloe versus placebo. A systematic review identified four qualifying clinical trials with generally positive but heterogeneous results.
CallosCientífico
Aloe vera gel contains polysaccharides, vitamins, and amino acids with anti-inflammatory and immunomodulatory properties relevant to skin rashes and hives. Herbal hydrogels containing aloe vera extract are under development specifically for topical urticaria symptom management per a 2025 systematic review. Topical application is widely used traditionally and supported by anti-inflammatory mechanistic data.
Dolor de cabeza (tensión)Científico
Aloe vera has been traditionally prescribed for rheumatoid arthritis (RA), and scientific evidence confirms anti-inflammatory mechanisms relevant to RA pathophysiology. Acemannan and anthraquinones modulate cytokines (TNF-α, IL-6, IFN-γ) central to RA. A 2025 PMC review specifically explored aloe vera anthraquinones as modulators of autoimmune/inflammaging mechanisms including RA.
Pérdida AuditivaCientífico
A 2008 clinical study found that a cream containing 0.5% aloe vera extract was more effective than placebo in reducing rosacea-related redness and inflammation. Karger's 2026 rosacea plant extract narrative review classifies Aloe vera as having clinical evidence in related dermatological conditions. Dermatologists recommend it as a calming moisturizer ingredient for rosacea skin.
Tos (húmeda)Científico
Aloe vera has been investigated in multiple clinical studies for wound healing and scar modulation. It reduces inflammation, stimulates fibroblast activity, and supports collagen synthesis. Comprehensive reviews cite it alongside onion extract and vitamin E as a recognized topical plant extract for scar management.
Costra lácteaCientífico
Aloe vera has extensive traditional use in ancient Egyptian, Indian, Chinese, and Greek medicine for skin conditions. Modern clinical evidence shows oral aloe sterols improve skin moisture, elasticity, and collagen density in aging subjects. Topically, its polysaccharides (acemannan) hydrate skin, stimulate fibroblast collagen synthesis, and demonstrate anti-aging effects confirmed in a 2025 systematic review.
Calambres (pierna)Científico
Multiple clinical trials show oral aloe vera gel supplementation significantly improves facial wrinkles and skin elasticity, increases type I procollagen gene expression, and decreases MMP-1 (collagen-degrading enzyme) expression. A 12-week double-blind RCT with Aloe sterol confirmed significant improvements in skin hydration, elasticity, and collagen score versus placebo.
QuistesCientífico
Oral aloe vera gel powder has been studied in animal models for prevention of UVB-induced reductions in skin elasticity and extracellular matrix damage. Clinical trials show oral aloe vera and aloe sterol supplementation reverse UV-related photoaging markers. Topically, aloe vera is widely used for sunburn and UV-induced erythema with documented efficacy.
DebilidadCientífico
Multiple RCTs and a systematic meta-analysis of five RCTs (415 participants) demonstrate that aloe vera supplementation significantly reduces serum triglycerides in pre-diabetic and early diabetic patients. A double-blind RCT in 72 pre-diabetic subjects found triglyceride levels significantly decreased after four weeks with 500 mg aloe vera extract.
Hernia HiatalCientífico
Multiple RCTs and a systematic review/meta-analysis (9 trials, 847 participants) found aloe vera gel has better clinical efficacy for oral ulcers versus controls (RR 2.25, 95% CI 1.25–4.06) and significantly shorter healing time. It also shows benefit for pressure ulcers and chronic skin ulcers through anti-inflammatory and mucosal-protective mechanisms.
SofocosCientífico
A randomized, double-blind, placebo-controlled trial in 42 vitiligo patients undergoing narrowband UVB phototherapy found topical aloe vera gel was an effective and safe adjunct to reduce phototherapy-related side effects. This represents the primary human clinical evidence linking aloe vera to vitiligo management.
DifteriaCientífico
Aloe vera gel has well-documented wound-healing activity, supported by in vitro studies, animal models, and clinical trials. It accelerates burn wound healing, stimulates fibroblast and keratinocyte proliferation, and shows anti-inflammatory and antimicrobial properties. Traditional use extends back thousands of years across multiple cultures.
Dolor AbdominalTradicional
Aloe vera gel has been used in Ayurveda, Traditional Chinese Medicine, and diverse folk traditions for abscesses and infected skin conditions. Scientific studies confirm antimicrobial and anti-inflammatory activity of compounds such as acemannan and aloin. A Cochrane review found insufficient high-quality clinical evidence specifically for wound healing.
Enfermedad de AddisonTradicional
Aloe vera (anthraquinone-free preparations) has longstanding traditional use and is a recognized supportive supplement for interstitial cystitis/bladder pain syndrome. The IC Network and clinicians treating IC list anthraquinone-free aloe as a soothing, calming agent for the urinary tract. Some IC patients report symptom relief with its use, though controlled clinical trial data are limited.
Antibióticos (efectos secundarios de los)Tradicional
Aloe vera gel has a long traditional history of use for soothing digestive complaints in children including constipation and gut irritation. Its mucilaginous polysaccharides (acemannan) coat the intestinal lining and have mild laxative effects. Traditional use in children for digestive complaints is documented across multiple cultures, though large pediatric-specific clinical trials are limited.
AsmaTradicional
Aloe vera gel is used in Ayurvedic and popular traditional medicine to soften corns and relieve pain, applying fresh gel directly to the corn site. Its well-documented anti-inflammatory and moisturizing properties provide biological plausibility. No dedicated clinical trials exist for this specific indication, but it is listed among recognized natural remedies by podiatry and Ayurvedic sources.
Ayudas Atléticas y para el EjercicioTradicional
Aloe vera is a widely used traditional remedy for dark circles, believed to hydrate the periorbital skin, soothe inflammation, and support skin elasticity. Traditional Ayurvedic formulations for under-eye dark circles commonly incorporate aloe vera. Scientific evidence is preliminary; some studies suggest aloe sterols may improve skin elasticity, but direct clinical trials on aloe vera for dark circles are limited.
Retraso del crecimientoTradicional
Aloe vera has a long traditional use in gastrointestinal inflammation and irritation. Authoritative integrative medicine resources for diverticulitis specifically identify aloe vera as a botanical agent that 'can help soothe and calm inflamed tissues' in the context of diverticulitis management. Its mucilaginous gel has been used traditionally to coat and protect gastrointestinal mucosa.
Congelación (prevención)Tradicional
Aloe vera is used traditionally in KP management for its soothing, moisturizing, and anti-inflammatory properties on the rough, irritated follicular skin characteristic of KP. It is recommended in natural KP care protocols as a topical application. Evidence is based on traditional use and aloe vera's established emollient and anti-inflammatory properties in dermatology broadly.
Insuficiencia Cardíaca CongestivaTradicional
Aloe vera gel is widely used traditionally and is recommended by hospital-based health sources for soothing the itch, redness, and inflammation of poison ivy rashes. Its anti-inflammatory and wound-healing properties are attributed to acemannan and other polysaccharides. While no clinical trials specifically test aloe vera for urushiol-induced dermatitis, its documented cooling and anti-inflammatory effects on skin make it a plausible and broadly recommended supportive remedy.
Estreñimiento (niños)Tradicional
Aloe vera has been traditionally used for skin healing, wound care, and post-surgical recovery for centuries across multiple cultures. Life Extension's peer-reviewed surgical recovery protocol notes aloe contains bioactive phytochemicals traditionally used to alleviate skin conditions and has been studied in wound healing contexts.
Enfermedad de CushingTradicional
Aloe vera has long traditional use for sore throat relief, exploiting its anti-inflammatory, antimicrobial, and soothing properties. Clinical data come primarily from studies on radiation-induced oral mucositis rather than infectious pharyngitis, limiting direct translational relevance.
Digestión (deficiente)Tradicional
Aloe vera latex (containing aloin) is a traditional stimulant laxative used for bowel cleansing; the gel is used as a digestive soother. Aloe is consistently included in colon cleanse formulations for its bowel-stimulating and gut-soothing properties, with traditional use spanning ancient Egypt through contemporary whole-body cleanse products.

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