Enfermedad del Hígado Graso

Allicin is the principal bioactive organosulfur compound in garlic responsible for its anti-H. pylori activity. It inhibits urease and other bacterial enzymes. In vitro studies confirm bactericidal activity against clinical H. pylori strains, and it is used in integrative protocols for H. pylori-associated gastritis.

Aloe vera gel possesses antimicrobial, anti-inflammatory, and mucosal-healing properties relevant to gastritis. Clinical trials show aloe vera reduces symptoms of gastric irritation, and animal studies confirm protection against alcohol-induced gastric mucosal damage. It is recognized in integrative medicine protocols for gastritis.

B. clausii has been studied specifically as adjunctive therapy during H. pylori eradication, the primary cause of bacterial gastritis. Two double-blind RCTs demonstrated significant reduction in antibiotic-associated GI side effects including diarrhea, nausea, and epigastric pain in patients receiving triple therapy. B. clausii does not directly treat H. pylori infection but reduces treatment-related gastric mucosal insult.

Propolis (bee glue) has demonstrated anti-H. pylori activity in vitro and in clinical studies. It contains flavonoids and phenolic acids with direct antibacterial and anti-inflammatory effects on the gastric mucosa. A 2014 World Journal of Gastroenterology review identified propolis as a clinically-researched natural remedy for H. pylori gastritis.

Berberine, an isoquinoline alkaloid from plants such as barberry and goldenseal, has demonstrated antimicrobial activity against H. pylori and anti-inflammatory effects in H. pylori-induced chronic gastritis in animal models. A meta-analysis of RCTs found berberine combined with triple therapy increases H. pylori eradication rates and reduces adverse effects such as nausea and diarrhea.

P. betle leaf extract has demonstrated gastroprotective activity against experimentally induced gastric ulceration and inflammation in multiple rodent models. The active compound allylpyrocatechol (APC) shows protective effects on gastric mucosa. Evidence is entirely preclinical.

Bifidobacterium species have demonstrated the highest H. pylori eradication potential among probiotic genera in meta-analyses. A network meta-analysis of 34 RCTs (>9,000 patients) found Bifidobacterium-Lactobacillus combinations achieved 78.3% eradication rates, outperforming single-strain approaches for H. pylori-associated gastritis.

Bifidobacterium bifidum has been studied as an adjunct probiotic for H. pylori-associated gastritis within multi-strain combinations. It contributes to the inhibitory effects against H. pylori colonization and the reduction of gastric mucosal inflammation seen with Bifidobacterium-Lactobacillus combination protocols.

Bifidobacterium lactis is used in combination probiotic formulations shown in clinical trials to improve H. pylori eradication rates and reduce gastric mucosal inflammation. A prospective trial combining B. lactis with L. acidophilus, Lactiplantibacillus plantarum, and S. boulardii found improved H. pylori eradication and fewer adverse effects.

Bifidobacterium longum has demonstrated inhibitory effects against H. pylori in vitro and in vivo and is used in multi-strain probiotic formulations for H. pylori-associated gastritis treatment. It contributes to gastric mucosal immune modulation and reduction of gastric inflammation.

Bromelain's proteolytic and anti-inflammatory properties are supported by multiple studies suggesting benefit in gastritis. It may protect GI tissues from inflammatory damage by modulating cytokines and prostaglandins, and its dual activity in both acidic and alkaline pH environments makes it active throughout the upper GI tract. PMC reviews identify gastritis as an indication supported by clinical and study evidence.

Fresh cabbage juice contains S-methylmethionine ('vitamin U') and glutamine, which stimulate gastric mucus production and protect the gastric mucosa. Early human clinical trials demonstrated that raw cabbage juice healed peptic ulcers (including gastric ulcers) significantly faster than standard care. Animal studies confirm that cabbage extract raises gastric pH and reduces acidity.

Capsaicin has demonstrated gastroprotective effects in humans, including reduced NSAID-induced gastric mucosal microbleeding and modulation of TRPV1/CGRP signaling in chronic gastritis patients. A clinical study in 198 healthy subjects and 178 GI disease patients established oral capsaicin as a gastroprotective agent.

Cat's claw has been used traditionally for gastritis, and scientific preclinical studies confirm anti-inflammatory and gastroprotective effects in gastric models. A 2020 MDPI review states it inhibits 'acute or chronic gastritis caused by high doses of NSAIDs.' Indigenous use for gastric ulcers is well-documented.

Clove essential oil has demonstrated anti-gastritis effects in animal models, and eugenol inhibits H. pylori (the primary cause of chronic gastritis) with documented MIC values. Anti-inflammatory effects on gastric mucosa are supported by multiple preclinical studies.

Clinical evidence supports berberine from Coptis chinensis in managing gastric ulcers, gastritis, and enteritis. The herb has been used in TCM for stomach inflammation for over 2,000 years. Mechanistic studies show berberine inhibits H. pylori and reduces gastric inflammatory pathways.

Cranberry's high proanthocyanidin content inhibits H. pylori adhesion to the gastric mucosa, potentially reducing gastritis risk. A registered clinical trial and preliminary human studies suggest cranberry reduces H. pylori density in the stomach. It is recognized in natural treatment reviews for gastritis.

Curcumin, the principal polyphenol of turmeric, inhibits H. pylori growth in vitro across multiple clinical strains and suppresses H. pylori-induced NF-κB-mediated gastric inflammation. Animal studies confirm reduced gastritis activity. A small clinical trial showed significant symptom improvement and reduction of serologic gastric inflammation markers despite limited H. pylori eradication.

EGCG is the major catechin in green tea and has demonstrated in vitro anti-H. pylori activity including inhibition of urease and reduction of bacterial adherence to gastric mucosa. It also reduces pro-inflammatory cytokine expression in gastric epithelial cells relevant to gastritis pathogenesis.

C. speciosa fruit triterpenoids have been evaluated for gastroprotective activity in both clinical and preclinical settings. Studies show that total triterpenoids (CSTT) reduce gastric mucosal damage, inhibit acid secretion, and modulate inflammatory cytokines. The fruit has been applied clinically in China for erosive gastritis as part of combination formulas.

Gamma oryzanol has documented clinical use in Japan for chronic gastritis, with multiple 1970s–1980s Japanese clinical studies published in peer-reviewed pharmacology journals reporting symptom relief. It reduces post-meal GI symptoms including pain, nausea, and vomiting in gastritis patients, possibly by acting on CNS control of digestion and directly on the stomach.

Gardenia jasminoides extract has been studied for protective effects in gastritis models, including H. pylori-associated gastritis and NSAID-induced gastropathy. Geniposide and genipin reduce CagA, VacA, IL-8, IFN-γ, and IL-1β in H. pylori-infected models. GFE protects gastric mucosa by upregulating PGE2 and MUC5AC and downregulating iNOS and NF-κB.

Gardenia jasminoides fruit extract (GJE) has shown gastroprotective effects against both NSAID-induced gastropathy and H. pylori-induced gastritis in rat models, by inhibiting NF-κB and iNOS signaling, restoring prostaglandin E2 and mucin expression, and reducing bacterial growth and mucosal inflammation. Evidence is preclinical; human clinical studies have not been completed.

Garlic (Allium sativum) and its organosulfur compounds, including allicin, have demonstrated direct anti-H. pylori activity in vitro and in vivo. Epidemiological data suggest populations with high garlic consumption have lower rates of H. pylori-associated gastric disease. Garlic is included in authoritative reviews of natural H. pylori treatments.

Gentiopicroside from Gentiana macrophylla has been demonstrated to protect against ethanol-induced gastric mucosal injury in mice. The mechanism involves antioxidant enhancement (SOD, glutathione), heat shock protein-70 upregulation, normalization of growth factors, and reduction of TNF-α, IL-6, and myeloperoxidase activity in gastric tissue.

Ginger (Zingiber officinale) has documented anti-inflammatory and gastroprotective properties. Bioactive compounds 6-gingerol and 6-shogaol inhibit inflammatory mediators in the gastric mucosa. Ginger is used in traditional medicine for gastric complaints worldwide and is included in integrative protocols for gastritis management.

Green tea polyphenols, particularly EGCG, inhibit H. pylori growth and urease activity, and reduce bacterial adhesion to gastric mucosa. Epidemiological and in vitro studies support a role in reducing H. pylori-associated gastric inflammation. Green tea catechins also exert direct anti-inflammatory effects on the gastric mucosa.

Honey demonstrates in vitro antibacterial activity against Helicobacter pylori, the primary cause of chronic gastritis, and has been proposed as an adjunct to standard eradication therapy. In vitro studies (PMC3074916) confirm some honey types inhibit H. pylori, and honey inhibits H. pylori urease activity. Human clinical trial evidence specifically targeting H. pylori-associated gastritis remains limited.

Bael fruit extracts have demonstrated gastroprotective effects in ethanol-induced and H. pylori LPS-induced gastric mucosal damage models in rodents, reducing gastric acid output, pepsin concentration, and oxidative damage to the mucosal lining. Traditional Ayurvedic texts describe bael as a remedy for 'Amlapitta' (hyperacidity and gastritis).

H. indicus has demonstrated anti-ulcerogenic and gastroprotective effects in animal studies, including protection against aspirin-induced gastric erosion. The anti-inflammatory and demulcent properties of the root provide mechanistic rationale for gastritis relief. Traditional use for digestive inflammation is extensively documented.

Zinc L-carnosine (polaprezinc), a chelated form containing 77% L-carnosine, has been approved in Japan for gastric mucosal protection and has RCT evidence for H. pylori-associated gastritis and chronic atrophic gastritis. Clinical trials show improvements in gastric mucosal markers, symptom control, and H. pylori eradication when added to standard triple therapy.

L-glutamine is a critical amino acid for gastric mucosal integrity and repair, and is used in integrative protocols for gastritis. Cabbage juice, historically used for gastritis, contains high levels of L-glutamine. It supports gastric mucosa regeneration and is listed among proposed natural treatments for gastritis in authoritative databases.

Lactobacillus acidophilus has been studied in multiple RCTs as adjunct probiotic therapy for H. pylori eradication and associated gastritis. Combined with other Lactobacillus strains and Bifidobacterium species, it improves eradication rates and reduces adverse effects of standard antibiotic therapy.

A yogurt-based clinical study found that an AB-yogurt containing L. bulgaricus (alongside L. acidophilus, B. lactis, and S. thermophilus) reduced gastritis activity by decreasing H. pylori density in colonized subjects. In vitro studies confirm L. bulgaricus strains inhibit H. pylori growth through organic acid production. The WGO notes Lactobacillus strains can reduce gastrointestinal side effects of H. pylori eradication therapies.

Lactobacillus casei has demonstrated efficacy as an adjunct probiotic in H. pylori eradication and is identified in authoritative reviews as one of the probiotic strains that can effectively reduce H. pylori infection associated with chronic gastritis. Multiple systematic reviews and meta-analyses support its use alongside standard therapies.

L. gasseri OLL2716 has been studied in multiple clinical trials for H. pylori-associated gastritis and dyspepsia. A previous study found that twice-daily OLL2716 yogurt for 8 weeks reduced H. pylori density and ameliorated gastritis. A multicenter RCT in 131 H. pylori-positive adults showed OLL2716 significantly reduced bloating and postprandial fullness.

Lactobacillus plantarum (now Lactiplantibacillus plantarum) has been included in multi-strain probiotic combinations shown in clinical trials to improve H. pylori eradication and reduce gastritis-related adverse effects. It contributes to competitive exclusion of H. pylori and modulation of gastric mucosal inflammatory responses.

Lactobacillus reuteri, particularly strain DSM 17648, has been studied in multiple RCTs as adjunct therapy for H. pylori eradication and gastritis. A 2024 meta-analysis of 8 RCTs (1,087 patients) found L. reuteri supplementation significantly increases eradication rates and reduces antibiotic-related adverse events.

Lactobacillus rhamnosus GG is one of the most studied probiotic strains for H. pylori eradication and gastritis management. It is specifically identified in systematic reviews and meta-analyses as effective in increasing H. pylori eradication rates and reducing side effects of antibiotic therapy for H. pylori gastritis.

Lactoferrin has been successfully used as an adjunct to standard H. pylori eradication therapy, which is the principal cause of chronic gastritis. RCTs show that adding bovine lactoferrin to triple or sequential therapy significantly improves H. pylori eradication rates and reduces side effects.

Deglycyrrhizinated licorice (DGL) has been studied in clinical trials for gastritis and peptic ulcer disease. It enhances gastric mucus production, promotes mucosal healing, and shows anti-H. pylori and anti-inflammatory activity. The ESCOP monograph lists licorice as an adjuvant therapy for gastric/duodenal ulcers and gastritis.

Multiple preclinical studies show limonene exerts gastroprotective effects against gastric mucosal inflammation by increasing mucus production, modulating prostaglandin E2, and reducing inflammatory cytokines. Citrus aurantium (limonene-rich) has traditional use specifically for gastritis and gastric disorders. At 50–250 mg/kg in rodents, limonene produced near-complete gastroprotection in ethanol and NSAID-induced models.

Lion's Mane has been used historically for gastritis and epigastric pain in traditional Chinese medicine. A clinical study in patients with gastritis found supplementation significantly reduced inflammation-related symptoms and improved mucosal healing. Preclinical data show inhibition of H. pylori and protection of gastric mucosa.

Marjoram extract has demonstrated gastroprotective effects in rat models, including reduction of gastric acid secretion and replenishment of protective gastric mucus. These preclinical findings are consistent with its ethnobotanical use for stomach pain.

Mastic gum (Pistacia lentiscus resin) has been used for over 2,500 years for gastric complaints and has demonstrated in vitro and in vivo bactericidal activity against H. pylori. A 1998 NEJM letter reported mastic kills H. pylori at very low doses. An RCT of 180 patients found supplementation of standard triple therapy with mastic gum achieved 92.2% H. pylori eradication.

MMSC has been evaluated in patients with chronic gastritis in clinical studies. A 6-month open study in 37 chronic gastritis patients receiving 300 mg/day of MMSC showed a statistically significant progressive reduction in GSRS dyspepsia scores and improvements in quality-of-life measures. A combination study with dexpanthenol also showed improved morphological status of the gastric mucosa.

Peppermint oil has documented in vitro and animal-model bactericidal activity against Helicobacter pylori, the primary causative agent of gastritis. It also exerts anti-inflammatory effects on gastric mucosa via menthol's suppression of COX-2, prostaglandins, and interleukins. Limited clinical application to gastritis directly has been studied.

Mucin composition changes dramatically across the spectrum of gastric disease from superficial gastritis to gastric cancer, as documented in large clinical biopsy studies. The gastric mucin layer protects the mucosa from acid, pepsin, and external injury. Disruption of mucin phenotype is directly linked to disease progression.

N-acetylcysteine (NAC) disrupts H. pylori biofilms and has mucolytic activity that increases antibiotic penetration of the gastric mucus layer, improving H. pylori eradication. It was included in a clinical trial evaluating non-antibiotic therapy for H. pylori-associated gastritis, where significant symptom improvement and reduction of gastric inflammation markers were observed.

Nigella sativa (black seed) seeds have been compared to standard triple therapy for H. pylori eradication in a published RCT. A 2010 study found that 2 g black seed plus omeprazole achieved 67% H. pylori eradication, comparable to triple antibiotic therapy (82%). Its active compound thymoquinone disrupts H. pylori cell membranes and reduces gastric mucosal inflammation.

Okra is documented in Turkish traditional medicine for gastritis and has preclinical evidence supporting gastroprotective mechanisms. Anti-adhesive compounds in okra prevent H. pylori adhesion to gastric mucosa, a key driver of gastritis. Animal studies show reduction of gastric edema, hemorrhage, and inflammatory cell infiltration.

OA's anti-inflammatory mechanisms (NF-κB inhibition, COX-2 suppression, tight junction restoration) are directly relevant to gastritis pathophysiology. It reduces gastric mucosal inflammatory markers in preclinical models, supported by multiple mechanistic studies.

Two clinical studies of over 150 subjects in total — including one specifically in patients with chronic stomach inflammation (gastritis) — found that papaya enzyme improved symptoms including stomach pain and inflammation versus control. Animal studies additionally show papain reduces gastric acid secretion. This constitutes meaningful scientific evidence, though study sizes are small.

A 2025 study in Frontiers in Immunology demonstrated that T. arvense ameliorates DSS-induced colitis in mice by modulating gut microbiota, suppressing TNF-α/NF-κB-driven inflammation, and preserving intestinal barrier integrity. Its constituent isovitexin directly mitigates TNF-α-induced intestinal epithelial damage. This preclinical evidence is relevant to gastritis and inflammatory gastrointestinal conditions.

Pepsinogen (the inactive precursor of pepsin) levels — particularly pepsinogen II (PgII) — are well-established clinical biomarkers of gastric mucosal inflammation and H. pylori-associated gastritis. Elevated serum PgII correlates significantly with active H. pylori infection and the degree of histologic gastritis. Pepsin itself, through its mucolytic activity and ability to degrade the mucus-bicarbonate barrier, contributes directly to gastric mucosal injury in the setting of inflammatory gastritis.

A berberine-free fraction of P. amurense bark showed significant anti-ulcer and anti-inflammatory activity in rat gastric models (Uchiyama et al., 1989), including reduction of gastric acid secretion and anti-cholera toxin effects. P. amurense has been documented in TCM and Kampo as a treatment for gastroenteritis, abdominal pain, and stomach inflammation. Nexrutine (P. amurense extract) is commercially used for gastroenteritis treatment.

Animal research shows that Zanthoxylum stem and root extracts improved gastrointestinal movement in mice with chronic gastritis. The EBSCO Research Starters and Healthline (citing peer-reviewed sources) both document this preclinical evidence alongside traditional use. Human clinical trial data remain absent.

Propolis has demonstrated direct anti-H. pylori bactericidal activity in vitro and in clinical studies, including activity against antibiotic-resistant strains. A 2014 World Journal of Gastroenterology review of natural treatments for H. pylori infection identified propolis as one of the natural agents with clinical research evidence. Its principal constituents include CAPE and flavonoids with anti-inflammatory and antibacterial actions.

Rosmarinic acid has demonstrated anti-inflammatory and gastroprotective effects in preclinical gastric mucosal injury models, reducing mucosal inflammation via NF-κB suppression and antioxidant activity. Traditional use of RA-containing Lamiaceae plants (rosemary, lemon balm) for gastric complaints provides complementary traditional context. Dedicated human gastritis RCTs with RA are absent.

Saccharomyces boulardii is the most extensively studied single probiotic strain for H. pylori eradication as adjunct therapy. A high-quality systematic review (2025, 19 RCTs, 5,036 cases) confirmed significant improvement in H. pylori eradication rates with S. boulardii supplementation. It also reduces antibiotic-associated side effects during H. pylori gastritis treatment.

P. hydropiper extracts have demonstrated gastric mucosal protection in animal models, inhibiting pro-inflammatory cytokines and oxidative stress in stomach tissue. Flavonoids (rutin, quercitrin, quercetin) are the primary active constituents. The plant is used in traditional Chinese medicine specifically for stomach and large intestine conditions.

Soursop leaf extracts exhibit gastroprotective activity in animal models of chemically induced gastric injury, protecting the gastric mucosa from damage. This is supported by multiple in vivo studies and is mechanistically linked to its antioxidant and anti-inflammatory phytochemistry.

SPMs are produced in gastric mucosa and are reduced in H. pylori-associated gastritis. LXA4 and resolvins counter neutrophilic gastric inflammation. SPMs protect against NSAID-induced gastric mucosal damage via 15-LOX and aspirin-triggered lipoxin pathways.

Sulforaphane is a potent bacteriostatic agent against H. pylori, the primary cause of chronic gastritis and peptic ulcers. It inhibits H. pylori in vitro and in vivo and has demonstrated anti-gastritis activity in human subjects in clinical studies.

Rat studies have shown A. calamus rhizome extract has inhibitory action on gastric secretion and antiulcerogenic activity, providing a preclinical basis for traditional use in gastritis. Traditional Ayurvedic and Unani use for gastric complaints is well-documented, though human clinical trial data are absent.

Gastroprotective and anti-gastritis activity of Swertia species is supported by preclinical studies and the traditional use of S. perennis (and S. chirayita) for gastritis. In vitro studies of S. perennis specifically investigate its utility in gastritis. A Bentham Science review highlights scientific studies supporting Swertia's role in treating gastritis and GI disorders.

T. tricuspidata methanol extract demonstrated significant anti-inflammatory activity in an HCl/EtOH-induced gastritis mouse model, suppressing NF-κB, MAPK, and JAK2 signaling pathways and reducing pro-inflammatory cytokines. TCM also attributes Trichosanthes to the stomach meridian, with traditional use for stomach heat and gastric discomfort.

Turmeric (Curcuma longa) and its principal active compound curcumin have demonstrated anti-H. pylori activity in vitro and anti-inflammatory gastric effects in animal and human studies. Turmeric extract was shown to inhibit 31 clinical H. pylori strains in a dose-dependent manner. Clinical studies show improvement in GERD/gastritis clinical scores.

Vitamin U (S-methylmethionine) from cabbage juice was used in early clinical studies for gastric ulcers and gastritis, with significant healing rates reported. It has been recognized as a gastroprotective factor that promotes gastric mucosal regeneration and reduces gastric acid-related damage.

Zinc (particularly zinc carnosine) is well-documented for strengthening the gastric mucosal lining and accelerating gastric epithelial healing in gastritis. Zinc carnosine has demonstrated in clinical trials the ability to protect against gastric mucosal damage, inhibit H. pylori, and reduce gastric inflammation. Zinc is listed among proposed natural treatments for gastritis in authoritative databases.

Agrimony has a documented traditional role in chronic gastritis and gastroduodenitis, supported by a 1982 clinical combination study (Chakarski) and in vitro evidence of activity against Helicobacter pylori, a key causative agent of gastritis. Its astringent and anti-inflammatory actions are the proposed mechanisms.

Ajwain is used traditionally for gastritis and stomach inflammation across Ayurvedic and Unani systems. Its carminative and antispasmodic properties provide symptomatic relief. However, its gastric acid-stimulating effects may make it contraindicated in some gastritis presentations. Preclinical anti-ulcer evidence provides partial mechanistic support.

Traditional use of A. galanga for gastritis is well-documented across Chinese, Indian, and Middle Eastern medicine. Preclinical data show gastroprotective effects with reduction of gastric wall lesions. No dedicated human trials for gastritis exist, though the traditional evidence base is extensive.

Anise is documented in ethnobotanical and traditional medicine texts as a treatment for gastritis, and antimicrobial activity against H. pylori-related bacteria has been noted mechanistically. Preclinical studies show mucosal-protective effects. No dedicated human clinical trial for gastritis has been conducted.

Banana and plantain have been used traditionally across South Asia and Africa to treat gastritis and gastric irritation, with unripe banana considered especially beneficial. In vivo and phytochemical studies confirm that banana flavonoids—particularly leucocyanidin—enhance gastric mucosal thickness and promote re-epithelialization, providing a plausible gastroprotective mechanism. Direct human RCT evidence for gastritis specifically is lacking.

Barberry has documented traditional use for gastritis and stomach inflammation, supported by its antimicrobial (including anti-H. pylori) and anti-inflammatory properties. It is used in Persian and European herbal traditions as a stomachic to ease gastric inflammation. No direct human RCT data for gastritis specifically are available.

Bayberry leaf tea boiled with other herbs was a traditional medicinal remedy for stomach pains and gastritis. The root bark was used as an astringent for chronic gastritis in North American herbal tradition. No clinical evidence exists.

Black cumin is documented in Unani and Islamic traditional medicine as a remedy for gastric complaints including gastritis. The PMC GI review documents gastroprotective, anti-inflammatory, and antibacterial (including H. pylori activity) properties in experimental models relevant to gastritis.

Bladderwrack's high mucilage and alginic acid content traditionally soothe inflamed gastric mucosa. It is listed in traditional herbal practice for gastritis alongside other mucoprotective herbs. No clinical trials exist for bladderwrack in gastritis specifically.

Borage leaves have traditional use for gastritis and stomach inflammation, recorded in European and other herbal traditions. The mucilaginous compounds in borage are credited with soothing inflamed gastric mucosa. No clinical trials have been conducted specifically for gastritis.

Cabbage juice has a long tradition of use for gastritis, heartburn, and gastrointestinal mucosal irritation across European and Asian herbal medicine. Traditional sources recommend 2–3 glasses of freshly extracted juice taken between meals to relieve gastritis and related upper GI discomfort. The 'vitamin U' (S-methylmethionine) found in cabbage is thought to support mucosal protection, though formal human trials specifically for gastritis are lacking.

Calendula infusion has a traditional history of use for gastritis and gastric mucosal inflammation across European and Asian herbal systems. In vitro work shows NF-κB inhibition in gastric epithelial cells. Human studies used herbal mixtures including calendula for gastric conditions with positive results, but calendula monotherapy RCTs for gastritis do not exist.

German chamomile (Matricaria recutita) has been used in European herbal medicine for gastritis and gastric irritation for centuries. Its flavonoids, notably apigenin, show gastroprotective effects in clinical and preclinical studies. The German Commission E approves chamomile for gastrointestinal spasms and inflammatory diseases of the GI tract.

Chen Pi is traditionally applied in TCM for gastritis-type presentations (epigastric pain, bloating, reduced appetite) and is listed in the Chinese Pharmacopoeia for digestive conditions. Modern studies confirm CRP polysaccharides protect against gastric mucosal injury.

Chickweed is used in herbal medicine for gastritis, with its demulcent mucilage soothing inflamed gastric mucosa and flavonoids providing anti-inflammatory effects. Multiple herbal sources list this among digestive indications. No clinical evidence is available.

Comfrey leaf and root have a long traditional use for gastritis and gastrointestinal inflammation, with mucilaginous compounds thought to protect the gastric mucosa. Brazilian traditional medicine in particular uses comfrey tea for gastritis. Drugs.com and historical pharmaceutical handbooks document this as a traditional internal indication, though no clinical trials support it and internal comfrey is contraindicated due to hepatotoxicity.

Classical TCM texts and pharmacological reviews document Fu Ling as a treatment for 'chronic gastritis, acute gastroenteric catarrh, and gastric atony.' The pachymic acid constituent has been noted for established effectiveness in chronic gastritis. TCM formulas incorporating Fu Ling are used for spleen-stomach disharmony underlying gastritis patterns.

Gentiana species are documented in traditional Chinese medicine and the Gentianaceae PMC review as treatments for gastritis. G. scabra and related species are used to clear gastric 'heat' and reduce gastric inflammation. Preclinical evidence shows gastroprotective properties of bitter principles from gentian root in rat gastric lesion models. No human RCTs for gastritis exist.

Gentian root is listed in traditional use sources—including RxList, Drugs.com, and referenced in the EMA historical use document—for gastritis. In TCM, G. scabra and G. lutea are used for gastritis and gastric heat. An animal study showed gentian extract reduced gastric acid output and protected gut lining against ulcers. Gentian is contraindicated in severe gastritis or ulcers in modern guidance due to its acid-stimulating properties.

G. littoralis is traditionally used in TCM for 'stomach-yin deficiency,' a pattern encompassing symptoms of gastritis such as gastric discomfort, dryness, and thirst. The Pharmacopoeia of the People's Republic of China documents stomach-related uses. The 2023 systematic review lists esophagitis among TCM clinical applications, suggesting gastric mucosal relevance.

Goldenseal is traditionally used for gastric inflammation and has been listed in herbal references for stomach ulcers and gastritis. Berberine's in vitro activity against Helicobacter pylori, a major gastritis pathogen, provides mechanistic rationale, but no human clinical trials of goldenseal for gastritis have been identified.

Amla has traditional use in Ayurveda specifically for reducing 'excess pitta' (gastric acid/heat), and its gastroprotective compounds mechanistically target gastric mucosal inflammation. PMC and traditional medicine sources document its use for reducing stomach acidity and protecting the gastric lining.

S. scardica has been documented in traditional medicine for gastrointestinal complaints including gastritis. Preclinical studies confirm gastroprotective activity comparable to ranitidine in rat ulcer models. The EMA recognizes its traditional use for mild gastrointestinal discomfort. No specific clinical study in gastritis patients has been conducted.

In TCM, honeysuckle acts on the Stomach meridian and is used for conditions characterized by 'heat in the stomach' including gastric inflammation. Folk prescriptions document its use for enteritis and digestive inflammation. No human clinical trials for honeysuckle specifically in gastritis have been identified.

Acacia nilotica bark is drunk for intestinal pain and stomach problems in traditional medicine across Africa and South Asia. The demulcent gum and tannin-rich bark have a pharmacological rationale for reducing gastric mucosal irritation. Gastroprotective effects are confirmed in animal models.

Indigo leaves are used in traditional Indian medicine for stomach complaints and gastrointestinal inflammation. Related Indigofera species (I. truxillensis) have shown gastroprotective activity in animal models. No human trial data exist specifically for gastritis from I. tinctoria leaves.

Lemon balm is traditionally used for gastrointestinal complaints including gastritis, upset stomach, and indigestion. The German Commission E approves it for functional GI complaints, and ESCOP recommends it for digestive disorders. Its antispasmodic and anti-inflammatory (COX/LOX inhibition) properties provide mechanistic plausibility, though no RCT specifically targeting gastritis exists.

Traditional use of mangosteen pericarp for gastrointestinal conditions including stomach complaints is documented across Southeast Asia. The antimicrobial and anti-inflammatory properties of xanthones are mechanistically relevant to Helicobacter pylori-associated gastritis. No human clinical trials have evaluated mangosteen specifically for gastritis.

Marshmallow root (Althaea officinalis) is widely used in traditional European herbal medicine for gastritis and gastric irritation. Its high mucilaginous polysaccharide content forms a protective layer over inflamed gastric mucosa. A 2010 clinical trial confirmed the traditional use of marshmallow preparations for treatment of irritated mucous membranes.

M. citrifolia is documented in traditional medicine systems across Asia and the Pacific for gastritis and stomach ailments. The 2016 Pharmacognosy Journal review and a 2024 ethnopharmacological review both list gastritis as a condition for which noni has 'proved beneficial.'

Nopal has documented traditional use for gastritis, stomachache, and gastrointestinal inflammation across Mexican, sub-Saharan, and other ethnopharmacological traditions. Preclinical mechanisms involving mucilage coating of gastric mucosa and anti-inflammatory polyphenols provide biological plausibility. No controlled human trials specifically addressing gastritis have been identified.

C. rotundus is traditionally used across Ayurveda, TCM, and Unani medicine for stomach inflammation, dyspepsia, and bowel disorders. Animal models demonstrate gastroprotective and anti-inflammatory effects relevant to gastritis. No clinical trials specifically targeting gastritis diagnosis have been published.

Ophiopogon japonicus is traditionally prescribed in TCM for stomach and gastrointestinal complaints including gastritis-type presentations. The herb's fluid-replenishing and yin-nourishing properties are applied to gastric dryness, thirst, and stomach discomfort. Documented in classical texts and ethnomedicinal literature.

Chronic atrophic gastritis from stomach yin deficiency is a well-established TCM indication for ophiopogon root. The Chinese Pharmacopoeia and classical texts record its use for clearing stomach heat, nourishing stomach yin, and treating digestive discomfort. It is commonly referenced in TCM clinical practice for atrophic gastritis.

Current herbal practice cites Oregon grape root as a primary treatment for gastritis and general digestive weakness. Its bitter alkaloids stimulate gastric secretions and its antimicrobial berberine content provides a rational basis against H. pylori-related gastritis. No clinical trials using Oregon grape for gastritis diagnosis have been published.

P. foetida is widely used by tribal communities across northeastern and southern India for gastritis, stomach swelling, indigestion, and abdominal pain. Multiple ethnobotanical surveys record this use. Preclinical gastroprotection data indirectly supports this application.

Peach leaf infusion is documented in both Eclectic medicine and broader traditional use for gastritis, gastrointestinal inflammation, and stomach irritability. The King's American Dispensatory specifically cites it as a 'valuable agent in gastritis.' No clinical trials exist.

Plantago lanceolata and P. major have documented traditional and empirical use for gastric mucosal inflammation (gastritis). The German Commission E and ESCOP monographs list gastric mucosal irritation as an empirical indication for P. lanceolata. Mucilage content provides a protective, demulcent coating on irritated mucosa.

Plantago major has documented traditional use for gastritis, stomach inflammation, and peptic complaints across multiple global traditions. Its mucilage content is proposed to coat and protect the gastric mucosa. Pectic polysaccharides from P. major have shown antiulcerogenic activity in rat models, supporting the gastroprotective rationale.

Traditional use of prickly pear for gastritis is widely documented in Latin American, Mediterranean, and Asian folk medicine. The mucilaginous cladode sap has demulcent properties. Animal studies suggest gastroprotective activity, but human clinical trial evidence is not available.

Prunus africana bark decoctions are used in African traditional medicine for gastrointestinal complaints including stomach pain, which encompasses gastritis-type symptoms. Documented across ethnomedicinal surveys in multiple African countries. The anti-inflammatory properties of bark phytosterols and triterpenes provide mechanistic plausibility for gastric mucosal inflammation reduction.

Purslane is traditionally used across multiple cultures for stomach and gastrointestinal disorders including gastritis. Its flavonoids (kaempferol, quercetin, apigenin) are reported to protect gastric mucosa, and animal studies show gastroprotective and antiulcerogenic activity. No human RCTs for gastritis specifically were identified.

Queen of the meadow is a traditional remedy for gastritis and gastrointestinal hyperacidity, documented in the ESCOP monograph and the British Herbal Pharmacopoeia, and referenced since 17th-century herbals. Pre-clinical gastroprotective evidence supports mucosal protection in gastritis-like conditions. No human trials have been conducted.

Radish is used traditionally in Ayurveda and Chinese folk medicine for stomach and intestinal inflammatory disorders. RxList includes stomach and intestinal disorders among radish's documented traditional uses. Animal evidence suggests gastroprotective effects but no gastritis-specific human studies exist.

Rhubarb root is traditionally used in TCM for stomach pain and gastric inflammation. Modern preclinical work shows its anthraquinone and tannin constituents suppress gastric inflammatory mediators and inhibit H. pylori, but robust human clinical trial data specifically for gastritis as a distinct indication are lacking.

Rose hip is documented in traditional European and German herbal medicine as a 'stomach tonic' used for stomach irritation, stomach spasms, and gastric inflammation. The mucilaginous and astringent properties of rose hip infusion are the proposed mechanism for protecting and soothing inflamed gastric mucosa.

Shepherd's purse is used in Russian folk medicine and among herbalists for gastritis and stomach irritation. A 1969 pharmacological study demonstrated anti-ulcer effects of ethanol extracts in stress-induced ulcer models in rats. Its astringent and anti-inflammatory properties are proposed to soothe inflamed gastric mucosa.

TCM uses Z. bungeanum for stomach ache and dyspepsia, and classical texts describe it as a stomachic and carminative remedy. Modern preclinical evidence shows anti-inflammatory effects in the gastrointestinal tract, but no human gastritis-specific trials exist.

Slippery elm (Ulmus rubra) bark contains mucilaginous polysaccharides that coat and soothe irritated gastric mucosa. It has a long history of use in North American traditional medicine for gastritis and digestive inflammation. A 2010 clinical study confirmed the traditional use of its mucilaginous preparations for irritated mucous membranes.

Slippery elm bark is traditionally used for gastritis and stomach irritation, with its mucilage proposed to coat and protect the gastric mucosa from acid and inflammatory insult. It is listed across multiple herbal references for this indication. Preliminary clinical data from multi-ingredient supplement studies are suggestive but not isolating.

Gastritis—inflammation of the stomach lining—is a documented traditional application for Solomon's seal as a demulcent and gastrointestinal anti-inflammatory. Herbal Reality and multiple contemporary herbal sources list gastritis among GI indications, consistent with the herb's mucilaginous and anti-inflammatory character.

Ornithogalum umbellatum is listed in homeopathic Materia Medica (Boericke) for chronic gastric inflammation, including gastric irritation, burning in the stomach, loss of appetite, and distension. It is also noted in homeopathic sources for gastric irritation and inflammation. These are traditional homeopathic indications without controlled clinical evidence.

Thyme has traditional use in European herbal medicine for gastric complaints including gastritis and gastric ulcers, documented in ethnopharmacological records. Serpylli herba (wild thyme) is traditionally used to treat gastric ulcers in Europe and North Africa per PMC pharmacological literature. Thymol's antimicrobial activity against Helicobacter pylori has been studied preclinically, providing mechanistic support.

T. cordifolia is documented in Ayurvedic texts as a treatment for dyspepsia, flatulence, and gastritis. Ethnopharmacological literature from PMC 5018348 lists it for gastrointestinal diseases including gastritis. Its antacid and gastroprotective properties from antioxidant mechanisms provide plausible mechanisms.

Wheatgrass is documented in traditional naturopathic and Ayurvedic literature as a remedy for gastritis. Chlorophyll's anti-inflammatory and potentially gastric-protective properties provide mechanistic context. No human clinical trial specifically addresses wheatgrass for gastritis.

Yarrow is traditionally used for gastritis across multiple cultures, supported by documented gastroprotective pharmacology in animal models. Preclinical studies show protection of the gastric mucosa via anti-inflammatory, antioxidant, and antisecretory mechanisms, but no human clinical trials on gastritis specifically exist.

Yellow Root is documented in traditional North American herbal medicine as a remedy for gastric irritation and inflammation, and its antimicrobial activity against H. pylori-class pathogens is supported by berberine's broad antimicrobial profile. No clinical trials on Yellow Root for gastritis have been identified.